Universität zu Köln

Schloesser, Hans Anton, Drebber, Uta, Urbanski, Alexander, Haase, Simon, Baltin, Christoph, Berlth, Felix ORCID: 0000-0002-3780-0728, Neiss, Susanne, von Bergwelt-Baildon, Michael, Fetzner, Ulrich Klaus, Warnecke-Eberz, Ute, Bollschweiler, Elfriede, Hoelscher, Arnulf Heinrich, Moenig, Stefan Paul and Alakus, Hakan (2017). Glucose transporters 1, 3, 6, and 10 are expressed in gastric cancer and glucose transporter 3 is associated with UICC stage and survival. Gastric Cancer, 20 (1). S. 83 - 92. NEW YORK: SPRINGER. ISSN 1436-3305

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Abstract

Background Due to proliferation and increased metabolism, cancer cells have high glucose requirements. The glucose uptake of cells is influenced by a group of membrane proteins denoted the glucose transporter family (Glut-1 to -12). Whereas increased expression and a negative correlation with survival have been described for Glut-1 in several types of cancer, the impact of other glucose transporters on tumor biology is widely unknown. In this retrospective study, gastric cancer specimens of 150 patients who underwent total gastrectomy between 2005 and 2010 were stained for Glut-1, -3, -6, and -10 by immunohistochemistry. Expression of Glut-1, -3, -6, and 10 was correlated to prognosis as well as clinical and pathological parameters. Glut-1, Glut-3, Glut-6, and Glut-10 were expressed in 22.0, 66.0, 38.0, and 43.3 % of the analyzed samples. Whereas Glut-1, -6, and -10 did not show a correlation with prognosis, positive staining for Glut-3 was associated with higher UICC stage and inferior prognosis. The mean overall survival was 38.6 months for Glut-3 positive patients, as compared to 51.2 months for Glut-3 negative patients (p < 0.05). Coexpression of two or more of the analyzed glucose transporters was correlated to inferior prognosis. Glut-3 and UICC stage were significant prognostic factors in multivariate analysis. All of the analyzed glucose transporters were expressed in a significant proportion of the gastric cancer samples. Glut-3 was associated with higher UICC stage and inferior prognosis. These findings are relevant to therapeutic approaches that target glucose metabolism as well as to imaging using radioactively labeled glucose.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schloesser, Hans Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Urbanski, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Haase, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Baltin, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Berlth, Felix UNSPECIFIED orcid.org/0000-0002-3780-0728 UNSPECIFIED Neiss, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Fetzner, Ulrich Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnecke-Eberz, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf Heinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Moenig, Stefan Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-247832
DOI:	10.1007/s10120-015-0577-x
Journal or Publication Title:	Gastric Cancer
Volume:	20
Number:	1
Page Range:	S. 83 - 92
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1436-3305
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PYRUVATE-DEHYDROGENASE KINASE-1; SQUAMOUS-CELL CARCINOMA; GASTROESOPHAGEAL CANCER; GENE-EXPRESSION; LUNG CARCINOMAS; POOR-PROGNOSIS; GLUT1; GLUCOSE-TRANSPORTER-1; OVEREXPRESSION; METABOLISM Multiple languages Oncology; Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24783