Universität zu Köln

Hautmann, Christopher, Rothenberger, Aribert and Doepfner, Manfred (2017). Daily Symptom Profiles of Children With ADHD Treated With Modified-Release Methylphenidate: An Observational Study. J. Atten. Disord., 21 (2). S. 120 - 129. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1557-1246

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Abstract

Objective: The aim was to identify subgroups of patients with ADHD with different daily symptom profiles and to characterize their response to modified-release methylphenidate (MR MPH) treatment, using data from the observational trial OBSEER. Method: OBSEER included patients aged 6 to 17 years receiving MR MPH under routine care. To detect subgroups, a latent class cluster analysis was applied. Sex, age, MR MPH dose, and emotional symptoms were considered predictors of response. Results: The analysis included 637 patients (81.3% male), with a mean age (standard deviation) of 10.1 (2.5) years. A two-class solution best fit the data, identifying a high-severity group (49.8%) with pronounced symptom reduction, and a low-severity group (50.2%) with minor changes throughout the day. Younger age, male sex, and higher MPH doses were predictive of the high-severity class. Conclusion: Children with ADHD treated with MR MPH are heterogeneous, and subgroups with differential treatment response can be identified.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hautmann, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothenberger, Aribert UNSPECIFIED UNSPECIFIED UNSPECIFIED Doepfner, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-248011
DOI:	10.1177/1087054713502233
Journal or Publication Title:	J. Atten. Disord.
Volume:	21
Number:	2
Page Range:	S. 120 - 129
Date:	2017
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	1557-1246
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT-HYPERACTIVITY-DISORDER; LONG-ACTING MEDICATIONS; LABORATORY SCHOOL; DOSE-RESPONSE; ADOLESCENTS; EFFICACY; HETEROGENEITY; FORMULATIONS; VARIABILITY Multiple languages Psychology, Developmental; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24801