Amos, Christopher I., Dennis, Joe, Wang, Zhaoming ORCID: 0000-0001-7556-3869, Byun, Jinyoung, Schumacher, Fredrick R., Gayther, Simon A., Casey, Graham, Hunter, David J., Sellers, Thomas A., Gruber, Stephen B., Dunning, Alison M., Michailidou, Kyriaki ORCID: 0000-0001-7065-1237, Fachal, Laura ORCID: 0000-0002-7256-9752, Doheny, Kimberly, Spurdle, Amanda B., Li, Yafang, Xiao, Xiangjun, Romm, Jane, Pugh, Elizabeth, Coetzee, Gerhard A., Hazelett, Dennis J., Bojesen, Stig E., Caga-Anan, Charlisse, Haiman, Christopher A., Kamal, Ahsan, Luccarini, Craig, Tessier, Daniel, Vincent, Daniel, Bacot, Francois, Van den Berg, David J., Nelson, Stefanie, Demetriades, Stephen, Goldgar, David E., Couch, Fergus J., Forman, Judith L., Giles, Graham G., Conti, David V., Bickeboeller, Heike, Risch, Angela ORCID: 0000-0002-8026-5505, Waldenberger, Melanie ORCID: 0000-0003-0583-5093, Brueske-Hohlfeld, Irene, Hicks, Belynda D., Ling, Hua, McGuffog, Lesley, Lee, Andrew, Kuchenbaecker, Karoline, Soucy, Penny, Manz, Judith, Cunningham, Julie M., Butterbach, Katja, Kote-Jarai, Zsofia, Kraft, Peter ORCID: 0000-0002-4472-8103, FitzGerald, Liesel, Lindstrom, Sara, Adams, Marcia, McKay, James D., Phelan, Catherine M., Benlloch, Sara, Kelemen, Linda E., Brennan, Paul, Riggan, Marjorie, O'Mara, Tracy A., Shen, Hongbing ORCID: 0000-0002-2581-5906, Shi, Yongyong ORCID: 0000-0003-1710-1505, Thompson, Deborah J., Goodman, Marc T., Nielsen, Sune F., Berchuck, Andrew, Laboissiere, Sylvie, Schmit, Stephanie L. ORCID: 0000-0001-5931-1194, Shelford, Tameka, Edlund, Christopher K., Taylor, Jack A., Field, John K., Park, Sue K., Offit, Kenneth, Thomassen, Mads, Schmutzler, Rita, Ottini, Laura, Hung, Rayjean J., Marchini, Jonathan, Al Olama, Ali Amin, Peters, Ulrike, Eeles, Rosalind A., Seldin, Michael F., Gillanders, Elizabeth, Seminara, Daniela, Antoniou, Antonis C., Pharoah, Paul D. P., Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Chanock, Stephen J., Simard, Jacques and Easton, Douglas F. (2017). The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers. Cancer Epidemiol. Biomarkers Prev., 26 (1). S. 126 - 136. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7755

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Abstract

Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits. Methods: The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers, and for ancestry analysis. The array was genotyped at selected sites and with prespecified replicate samples to permit evaluation of genotyping accuracy among centers and by ethnic background. Results: The OncoArray consortium genotyped 447,705 samples. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis. Conclusions: Results from these analyses will enable researchers to identify new susceptibility loci, perform fine-mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental, and lifestyle-related exposures. Impact: Ongoing analyses will shed light on etiology and risk assessment for many types of cancer. (C)2016 AACR.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Amos, Christopher I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dennis, JoeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, ZhaomingUNSPECIFIEDorcid.org/0000-0001-7556-3869UNSPECIFIED
Byun, JinyoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, Fredrick R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gayther, Simon A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casey, GrahamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunter, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sellers, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruber, Stephen B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunning, Alison M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michailidou, KyriakiUNSPECIFIEDorcid.org/0000-0001-7065-1237UNSPECIFIED
Fachal, LauraUNSPECIFIEDorcid.org/0000-0002-7256-9752UNSPECIFIED
Doheny, KimberlyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spurdle, Amanda B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, YafangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xiao, XiangjunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romm, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pugh, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coetzee, Gerhard A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hazelett, Dennis J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojesen, Stig E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caga-Anan, CharlisseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haiman, Christopher A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamal, AhsanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luccarini, CraigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tessier, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vincent, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bacot, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van den Berg, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demetriades, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Couch, Fergus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forman, Judith L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giles, Graham G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conti, David V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickeboeller, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Risch, AngelaUNSPECIFIEDorcid.org/0000-0002-8026-5505UNSPECIFIED
Waldenberger, MelanieUNSPECIFIEDorcid.org/0000-0003-0583-5093UNSPECIFIED
Brueske-Hohlfeld, IreneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hicks, Belynda D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ling, HuaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuffog, LesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuchenbaecker, KarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soucy, PennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manz, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cunningham, Julie M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butterbach, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kote-Jarai, ZsofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraft, PeterUNSPECIFIEDorcid.org/0000-0002-4472-8103UNSPECIFIED
FitzGerald, LieselUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindstrom, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adams, MarciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McKay, James D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phelan, Catherine M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benlloch, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kelemen, Linda E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brennan, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riggan, MarjorieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Mara, Tracy A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shen, HongbingUNSPECIFIEDorcid.org/0000-0002-2581-5906UNSPECIFIED
Shi, YongyongUNSPECIFIEDorcid.org/0000-0003-1710-1505UNSPECIFIED
Thompson, Deborah J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goodman, Marc T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nielsen, Sune F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berchuck, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laboissiere, SylvieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmit, Stephanie L.UNSPECIFIEDorcid.org/0000-0001-5931-1194UNSPECIFIED
Shelford, TamekaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edlund, Christopher K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, Jack A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Field, John K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Sue K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Offit, KennethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomassen, MadsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ottini, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hung, Rayjean J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchini, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al Olama, Ali AminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, Rosalind A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seldin, Michael F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gillanders, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seminara, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, Paul D. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chenevix-Trench, GeorgiaUNSPECIFIEDorcid.org/0000-0002-1878-2587UNSPECIFIED
Chanock, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-248308
DOI: 10.1158/1055-9965.EPI-16-0106
Journal or Publication Title: Cancer Epidemiol. Biomarkers Prev.
Volume: 26
Number: 1
Page Range: S. 126 - 136
Date: 2017
Publisher: AMER ASSOC CANCER RESEARCH
Place of Publication: PHILADELPHIA
ISSN: 1538-7755
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; PROSTATE-CANCER; BREAST-CANCER; ENVIRONMENT INTERACTIONS; MENDELIAN RANDOMIZATION; RISK; LUNG; VARIANTS; RAREMultiple languages
Oncology; Public, Environmental & Occupational HealthMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24830

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