Universität zu Köln

Xu, Li, He, Jianzheng, Kaiser, Andrea, Graeber, Nikolas, Schlaeger, Laura, Ritze, Yvonne and Scholz, Henrike (2016). A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila. PLoS One, 11 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Attraction to ethanol is common in both flies and humans, but the neuromodulatory mechanisms underlying this innate attraction are not well understood. Here, we dissect the function of the key regulator of serotonin signaling-the serotonin transporter-in innate olfactory attraction to ethanol in Drosophila melanogaster. We generated a mutated version of the serotonin transporter that prolongs serotonin signaling in the synaptic cleft and is targeted via the Gal4 system to different sets of serotonergic neurons. We identified four serotonergic neurons that inhibit the olfactory attraction to ethanol and two additional neurons that counteract this inhibition by strengthening olfactory information. Our results reveal that compensation can occur on the circuit level and that serotonin has a bidirectional function in modulating the innate attraction to ethanol. Given the evolutionarily conserved nature of the serotonin transporter and serotonin, the bidirectional serotonergic mechanisms delineate a basic principle for how random behavior is switched into targeted approach behavior.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xu, Li UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Jianzheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeber, Nikolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaeger, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritze, Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-252677
DOI:	10.1371/journal.pone.0167518
Journal or Publication Title:	PLoS One
Volume:	11
Number:	12
Date:	2016
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADULT DROSOPHILA; PLACE PREFERENCE; OLFACTORY CENTER; COCAINE REWARD; ANTENNAL LOBE; TRANSPORTER; MELANOGASTER; EXPRESSION; DOPAMINE; AVERSION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25267