Universität zu Köln

Fiess, Achim, Christian, Luka, Koelb-Keerl, Ruth, Knuf, Markus, Kirchhof, Bernd, Muether, Philipp S. and Bauer, Jacqueline (2016). Peripapillary Choroidal Thickness in Former Preterm and Full-Term Infants Aged From 4 to 10 Years. Invest. Ophthalmol. Vis. Sci., 57 (15). S. 6548 - 6554. ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. ISSN 1552-5783

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Abstract

PURPOSE. The aim of the study was to investigate peripapillary choroidal thickness in former preterm and full-term infants with spectral-domain optical coherence tomography (SD-OCT). METHODS. Subanalysis of infants with successful peripapillary choroidal thickness measurements of a prospective, controlled, cross-sectional, hospital-based study in a tertiary center of maximum care. The study examined 503 infants aged 4 to 10 years at the time of examination. Infants were divided into different groups: group 1 born with gestational age (GA) >= 37 weeks, group 2 born with GA between 29 and 32 weeks without ROP (retinopathy of prematurity), group 3 born with GA <= 28 weeks without ROP, and group 4 born with GA <= 32 weeks and presence of ROP. RESULTS. Peripapillary choroidal measurements were available for 388 of 503 participants. No significant differences were found among the four groups for global peripapillary choroidal thickness. Multivariable analysis revealed no association with low GA, birth weight, ROP occurrence, perinatal adverse events, and logMAR visual acuity. Only infants born small for GA (SGA) revealed peripapillary choroidal thinning in the superior (P = 0.033) and nasal (P = 0.024) sectors compared with infants born appropriate for GA (AGA). Infants SGA had lower visual acuity than AGA infants (0.03 +/- 0.07 logMAR SGA versus 0.01 +/- 0.05 logMAR AGA; P = 0.029). CONCLUSIONS. Our results indicate that prematurity itself does not affect choroidal thickness in the peripapillary region. Only infants born SGA revealed peripapillary choroidal thinning compared with AGA infants. Our data indicate that fetal growth restriction leads to choroidal long-term alterations in the peripapillary region.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fiess, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Christian, Luka UNSPECIFIED UNSPECIFIED UNSPECIFIED Koelb-Keerl, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Knuf, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-253635
DOI:	10.1167/iovs.16-20128
Journal or Publication Title:	Invest. Ophthalmol. Vis. Sci.
Volume:	57
Number:	15
Page Range:	S. 6548 - 6554
Date:	2016
Publisher:	ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Place of Publication:	ROCKVILLE
ISSN:	1552-5783
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; PERINATAL SURVEY DATA; ANTHROPOMETRIC DIMENSIONS; PERCENTILE VALUES; NEONATES ANALYSIS; HEALTHY-SUBJECTS; 16 STATES; RETINOPATHY; PREMATURITY; GUIDELINES Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25363