Universität zu Köln

Lingen, Verena, Luning, Anna, Krest, Alexander, Deacon, Glen B., Schur, Julia, Ott, Ingo ORCID: 0000-0002-8087-4618, Pantenburg, Ingo, Meyer, Gerd and Klein, Axel ORCID: 0000-0003-0093-9619 (2016). Labile Pd-sulphur and Pt-sulphur bonds in organometallic palladium and platinum complexes [(COD)M(alkyl) (S-ligand)](n+)-A speciation study. J. Inorg. Biochem., 165. S. 119 - 128. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-3344

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Abstract

Reaction of various sulphur ligands L (SEt-, SPh-, SC6F4H-4(-), SEt2, Sfflu(2), SnBu2, DMSO, DPSO) with the precursors [(COD)M(R)Cl] (COD = 1,5-cyclooctadiene, M = Pd or Pt; R = methyl (Me) or benzyl (Bn); DMSO = di methyl sulfoxide; DPSO = diphenyl sulfoxide) allowed isolation and characterisation of mononuclear neutral (n = 0) or cationic (n = 1) complexes [(COD)Pt(R)(LV. Reaction of L-cysteine (HCys) with [(COD)Pt(Me)Cl] under similar conditions gave the binuclear cationic complex in [{(COD)Pt(Me))(2)(mu-Cys)]Cl. Detailed NMR spectroscopy and single crystal X-ray diffraction in the case of [(COD)Pt(Me)(SEt2)][SbF6] and [(COD)Pt(Me)(DMSO)][SbF6] reveal markedly labilised Pt-S bonds as a consequence of the highly covalent Pt C bonds of the R coligands in these organometallic species. Cationic charge (n = 1) seems to lower the Pt-S bond strength further. Consequently, most of these complexes are not stable long-term in aqueous DMF (N,Ndimethylformamide) solutions. This made the evaluation of their antiproliferative properties towards HT-29 colon carcinoma and MCF-7 breast adenocarcinoma cell lines impossible. Only the two complexes l(COD)Pt(R)(SC6F4H-4)1 with R = Me or SC6F4H-4 coligands could be tested with the R = Me complex showing promising activity (in the range of cisplatin), while the R = SC6F4H-4 derivative is largely inactive, as were the phosphane complexes Rdppe)Pt(SC6F4H-4)(2)] (dppe = 1,2-bis(diphenylphosphino)ethane), cisI(PPh3)(2)Pt(SC6F4H-4)2] and cis-[(PPh3)(2)PtCl2] which were tested for comparison. In turn, our findings might pave the way to new Pt anti-cancer drugs with largely reduced unwanted depletion of incorporated drugs and reduced side-effects from binding to S-containing biomolecules. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lingen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Luning, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Krest, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Deacon, Glen B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schur, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Ingo UNSPECIFIED orcid.org/0000-0002-8087-4618 UNSPECIFIED Pantenburg, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Axel UNSPECIFIED orcid.org/0000-0003-0093-9619 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-253968
DOI:	10.1016/j.jinorgbio.2016.06.009
Journal or Publication Title:	J. Inorg. Biochem.
Volume:	165
Page Range:	S. 119 - 128
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-3344
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SODIUM DODECYL-SULFATE; PT-195 NMR; L-CYSTEINE; CRYSTAL-STRUCTURE; L-METHIONINE; CIS-INFLUENCE; X-RAY; MONOMETHYL-PLATINUM(II) COMPLEXES; METALLOINTERCALATION REAGENTS; MOLECULAR-STRUCTURE Multiple languages Biochemistry & Molecular Biology; Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25396