Universität zu Köln

Scholz, Rebecca and Langmann, Thomas (2016). Gut flora connects obesity with pathological angiogenesis in the eye. EMBO Mol. Med., 8 (12). S. 1361 - 1364. HOBOKEN: WILEY. ISSN 1757-4684

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Abstract

Neovascular age-related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well-known predisposing factor for nvAMD but how this metabolic disorder modulates angiogenesis in the posterior eye segment was largely unknown. In this issue of EMBO Molecular Medicine, Andriessen etal () show that high-fat diet-induced obesity causes dysbiosis in the gut that drives retinal inflammation and pathological angiogenesis in a mouse model of laser-induced choroidal neovascularization (CNV).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scholz, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254147
DOI:	10.15252/emmm.201607165
Journal or Publication Title:	EMBO Mol. Med.
Volume:	8
Number:	12
Page Range:	S. 1361 - 1364
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1757-4684
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MICROBIOTA Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25414