Universität zu Köln

Larenas Linnemann, D. E. S., Singh, J., Rosario, N., Esch, R., Matta, J. J., Maspero, J., Michels, A. and Moesges, R. (2016). Similar biological activity in skin prick test for Oralair((R)) (8200 BAU) and Grazax((R)) (6200 BAU) reinforces effective SLIT dosing level. Allergy, 71 (12). S. 1782 - 1787. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

In Europe, allergen extracts are standardized based on skin prick wheal size in 20-30 allergic subjects. To understand the biological activity of clinically effective Sublingual immunotherapy, we used this method to determine the biological activity of solution and tablet Timothy grass pollen (TIM) extracts, compared to an FDA-approved extract (Reference) of 10 000 BAU/ml. Blinded, quadruplicate skin prick tests with concentrate and three serial half-log dilutions allowed the construction of a semilogarithmic regression line per extract. Bioequivalent allergy units (BAU) values were obtained from the comparison with reference. Extracts and dilutions showed a neat linear dose response (all: R-2 > 0.98) in 33 rhinitis patients. Relative potencies: Staloral((R)) 12 000 BAU/ml, Soluprick((R)) 10 300 BAU/ml, Oralair((R)) 8200 BAU, and Grazax((R)) 6200 BAU. Even though all extract concentrates differed in wheal size (P = 0.01-0.001), Grazax((R)) producing a 25% smaller wheal size than Oralair((R)), and the biological activity of these clinically effective TIM tablets led in the same range (6200-8200 BAU; 0.92-1.23 cm(2)). SLIT dose-finding studies for other pollens might start with allergen extracts producing 1.1 cm(2) wheal surface.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Larenas Linnemann, D. E. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Singh, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosario, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Esch, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Matta, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maspero, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254534
DOI:	10.1111/all.12998
Journal or Publication Title:	Allergy
Volume:	71
Number:	12
Page Range:	S. 1782 - 1787
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1398-9995
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBLINGUAL IMMUNOTHERAPY Multiple languages Allergy; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25453