Dichgans, Martin, Wardlaw, Joanna ORCID: 0000-0002-9812-6642, Smith, Eric, Zietemann, Vera, Seshadri, Sudha ORCID: 0000-0001-6135-2622, Sachdev, Perminder ORCID: 0000-0002-9595-3220, Biessels, Geert Jan, Fazekas, Franz, Benavente, Oscar, Pantoni, Leonardo, De Leeuw, Frankerik, Norrving, Bo, Matthews, Paul, Chen, Christopher ORCID: 0000-0002-1047-9225, Mok, Vincent ORCID: 0000-0002-8102-8835, Duering, Marco, Whiteley, Will, Shuler, Kirsten, Alonso, Alvaro ORCID: 0000-0002-2225-8323, Black, Sandra E., Brayne, Carol ORCID: 0000-0001-5307-663X, Chabriat, Hugues ORCID: 0000-0001-8436-6074, Cordonnier, Charlotte ORCID: 0000-0002-5697-6892, Doubal, Fergus, Duzel, Emrah, Ewers, Michael, Frayne, Richard ORCID: 0000-0003-0358-1210, Hachinski, Vladimir, Ikram, Mohammad Arfan, Jessen, Frank, Jouvent, Eric ORCID: 0000-0001-7797-2236, Linn, Jennifer, O'Brien, John ORCID: 0000-0002-0837-5080, van Oostenbrugge, Robert, Malik, Rainer, Mazoyer, Bernard, Schmidt, Reinhold, Sposato, Luciano A., Stephan, Blossom, Swartz, Richard H., Vernooij, Meike, Viswanathan, Anand, Werring, David ORCID: 0000-0003-2074-1861, Abe, Koji, Allan, Louise, Arba, Francesco ORCID: 0000-0003-3941-7383, Bae, Hee-Joon, Bath, Philip M. W., Bordet, Regis, Breteler, Monique, Choi, Seong, Deary, Ian, DeCarli, Charles, Ebmeier, Klaus, Feng, Lei ORCID: 0000-0002-4414-9910, Greenberg, Steven M., Ihara, Masafumi ORCID: 0000-0002-7102-4048, Kalaria, Rajesh, Kim, SanYun, Lim, Jae-Sung ORCID: 0000-0001-6157-2908, Lindley, Richard I., Mead, Gillian, Murray, Alison, Quinn, Terry, Ritchie, Craig, Sacco, Ralph, Salman, Rustam Al-Shahi, Sprigg, Nikola, Sudlow, Cathie ORCID: 0000-0002-7725-7520, Thomas, Alan, van Boxtel, Martin, van der Grond, Jeroen, van der Lugt, Aad and Yang, Yuan-Han (2016). METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimers. Dement., 12 (12). S. 1235 - 1250. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1552-5279

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Abstract

Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically silent cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY license

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dichgans, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wardlaw, JoannaUNSPECIFIEDorcid.org/0000-0002-9812-6642UNSPECIFIED
Smith, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zietemann, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seshadri, SudhaUNSPECIFIEDorcid.org/0000-0001-6135-2622UNSPECIFIED
Sachdev, PerminderUNSPECIFIEDorcid.org/0000-0002-9595-3220UNSPECIFIED
Biessels, Geert JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fazekas, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benavente, OscarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantoni, LeonardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Leeuw, FrankerikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Norrving, BoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matthews, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, ChristopherUNSPECIFIEDorcid.org/0000-0002-1047-9225UNSPECIFIED
Mok, VincentUNSPECIFIEDorcid.org/0000-0002-8102-8835UNSPECIFIED
Duering, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whiteley, WillUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shuler, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alonso, AlvaroUNSPECIFIEDorcid.org/0000-0002-2225-8323UNSPECIFIED
Black, Sandra E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brayne, CarolUNSPECIFIEDorcid.org/0000-0001-5307-663XUNSPECIFIED
Chabriat, HuguesUNSPECIFIEDorcid.org/0000-0001-8436-6074UNSPECIFIED
Cordonnier, CharlotteUNSPECIFIEDorcid.org/0000-0002-5697-6892UNSPECIFIED
Doubal, FergusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duzel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewers, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frayne, RichardUNSPECIFIEDorcid.org/0000-0003-0358-1210UNSPECIFIED
Hachinski, VladimirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ikram, Mohammad ArfanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jouvent, EricUNSPECIFIEDorcid.org/0000-0001-7797-2236UNSPECIFIED
Linn, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Brien, JohnUNSPECIFIEDorcid.org/0000-0002-0837-5080UNSPECIFIED
van Oostenbrugge, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malik, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mazoyer, BernardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, ReinholdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sposato, Luciano A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephan, BlossomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swartz, Richard H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vernooij, MeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viswanathan, AnandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werring, DavidUNSPECIFIEDorcid.org/0000-0003-2074-1861UNSPECIFIED
Abe, KojiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allan, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arba, FrancescoUNSPECIFIEDorcid.org/0000-0003-3941-7383UNSPECIFIED
Bae, Hee-JoonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bath, Philip M. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bordet, RegisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breteler, MoniqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choi, SeongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deary, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
DeCarli, CharlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ebmeier, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feng, LeiUNSPECIFIEDorcid.org/0000-0002-4414-9910UNSPECIFIED
Greenberg, Steven M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ihara, MasafumiUNSPECIFIEDorcid.org/0000-0002-7102-4048UNSPECIFIED
Kalaria, RajeshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, SanYunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lim, Jae-SungUNSPECIFIEDorcid.org/0000-0001-6157-2908UNSPECIFIED
Lindley, Richard I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mead, GillianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murray, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quinn, TerryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritchie, CraigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sacco, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salman, Rustam Al-ShahiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sprigg, NikolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sudlow, CathieUNSPECIFIEDorcid.org/0000-0002-7725-7520UNSPECIFIED
Thomas, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Boxtel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Grond, JeroenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Lugt, AadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, Yuan-HanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-254599
DOI: 10.1016/j.jalz.2016.06.004
Journal or Publication Title: Alzheimers. Dement.
Volume: 12
Number: 12
Page Range: S. 1235 - 1250
Date: 2016
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WHITE-MATTER HYPERINTENSITIES; STRUCTURAL NETWORK EFFICIENCY; SMALL-VESSEL DISEASE; ALZHEIMERS-DISEASE; PARKINSONIAN SIGNS; STROKE SURVIVORS; GAIT DISORDERS; LACUNAR STROKE; DEMENTIA; IMPAIRMENTMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/25459

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