Universität zu Köln

Bischof, Gerard N., Jessen, Frank, Fliessbach, Klaus, Dronse, Julian, Hammes, Jochen, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Onur, Oezguer, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Kukolja, Juraj ORCID: 0000-0003-1569-3287, Drzezga, Alexander and van Eimeren, Thilo ORCID: 0000-0002-6951-2325 (2016). Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease. Ann. Clin. Transl. Neurol., 3 (12). S. 934 - 940. HOBOKEN: WILEY-BLACKWELL. ISSN 2328-9503

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Abstract

In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [F-18]AV-1451) and beta-amyloid burden (measured with [C-11]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [F-18]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of A and tau to neurodegeneration in Alzheimer's disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Dronse, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Onur, Oezguer UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254634
DOI:	10.1002/acn3.339
Journal or Publication Title:	Ann. Clin. Transl. Neurol.
Volume:	3
Number:	12
Page Range:	S. 934 - 940
Date:	2016
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	2328-9503
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROFIBRILLARY TANGLES; BETA; PATHOLOGY; BRAIN; HYPOMETABOLISM; DEMENTIA; ACCUMULATION; PROTEIN Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25463