Universität zu Köln

Berendes, Volker ORCID: 0000-0002-2941-8406, Zill, Sasha N., Bueschges, Ansgar and Bockemuehl, Till (2016). Speed-dependent interplay between local pattern-generating activity and sensory signals during walking in Drosophila. J. Exp. Biol., 219 (23). S. 3781 - 3794. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9145

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Abstract

In insects, the coordinated motor output required for walking is based on the interaction between local pattern-generating networks providing basic rhythmicity and leg sensory signals, which modulate this output on a cycle-to-cycle basis. How this interplay changes speed-dependently and thereby gives rise to the different coordination patterns observed at different speeds is not sufficiently understood. Here, we used amputation to reduce sensory signals in single legs and decouple them mechanically during walking in Drosophila. This allowed for the dissociation between locally generated motor output in the stump and coordinating influences from intact legs. Leg stumps were still rhythmically active during walking. Although the oscillatory frequency in intact legs was dependent on walking speed, stumps showed a high and relatively constant oscillation frequency at all walking speeds. At low walking speeds we found no strict cycle-to-cycle coupling between stumps and intact legs. In contrast, at high walking speeds stump oscillations were strongly coupled to the movement of intact legs on a one-to-one basis. Although during slow walking there was no preferred phase between stumps and intact legs, we nevertheless found a preferred time interval between touch-down or lift-off events in intact legs and levation or depression of stumps. Based on these findings, we hypothesize that, as in other insects, walking speed in Drosophila is predominantly controlled by indirect mechanisms and that direct modulation of basic pattern-generating circuits plays a subsidiary role. Furthermore, interleg coordination strength seems to be speed-dependent and greater coordination is evident at higher walking speeds.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Berendes, Volker UNSPECIFIED orcid.org/0000-0002-2941-8406 UNSPECIFIED Zill, Sasha N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Bockemuehl, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254876
DOI:	10.1242/jeb.146720
Journal or Publication Title:	J. Exp. Biol.
Volume:	219
Number:	23
Page Range:	S. 3781 - 3794
Date:	2016
Publisher:	COMPANY OF BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9145
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INSECT CARAUSIUS-MOROSUS; TIBIAL CAMPANIFORM SENSILLA; MOTOR-DRIVEN BELT; STICK INSECT; LEG COORDINATION; RHYTHMIC PATTERNS; JOINT CONTROL; MOVEMENTS; BEHAVIOR; COCKROACHES Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25487