Universität zu Köln

Loehrer, Philipp Alexander ORCID: 0000-0002-5279-2156, Nettersheim, Felix Sebastian, Jung, Fabienne, Weber, Immo ORCID: 0000-0003-2979-234X, Huber, Carlo, Dembek, Till Anselm ORCID: 0000-0001-7023-146X, Pelzer, Esther Annegret, Fink, Gereon Rudolf, Tittgemeyer, Marc and Timmermann, Lars (2016). Ageing changes effective connectivity of motor networks during bimanual finger coordination. Neuroimage, 143. S. 325 - 343. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Bimanual finger coordination declines with age. However, relatively little is known about the neurophysiological alterations in the motor-system causing this decline. In the present study, we used 128 channel electroencephalography (EEG) to evaluate causal interactions of cortical, motor-related brain areas. Right-handed young and elderly subjects performed complex temporally and spatially coupled as well as temporally coupled and spatially uncoupled finger tappings. Employing dynamic causal modelling (DCM) for induced responses, we inferred task-induced effective connectivity within a core motor network comprising bilateral primary motor cortex (M1), lateral premotor cortex (1PM), supplementary motor area (SMA), and prefrontal cortex (PFC). Behavioural analysis showed significantly increased error rates and performance times for elderly subjects, confirming that motor functions decrease with ageing. Additionally, DCM analysis revealed that this age-related decline can be associated with specific alterations of interhemispheric and prefrontal to premotor connectivity. Young and elderly subjects exhibited inhibitory left to right M1-M1 coupling during performance of temporally and spatially coupled movements. Effects of ageing on interhemispheric connectivity particularly emerged when movements became spatially uncoupled. Here, elderly participants still expressed inhibitory left to right M1-M1 coupling, whereas no such connection was present in the young. Furthermore, ageing affected prefrontal to premotor connectivity. In all conditions, elderly subjects showed significant couplings from left PFC to left 1PM. In contrast, young participants exhibited left PFC to SMA connections. These results demonstrate that (i) in spatially uncoupled movements interhemispheric MI-connectivity increases with age and (ii) support the idea that ageing is associated with enhanced lateral prefrontal to premotor coupling (PFC to IPM) and hypoactivation of a medial pathway (PFC to SMA) within the dominant hemisphere. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loehrer, Philipp Alexander UNSPECIFIED orcid.org/0000-0002-5279-2156 UNSPECIFIED Nettersheim, Felix Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Fabienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Immo UNSPECIFIED orcid.org/0000-0003-2979-234X UNSPECIFIED Huber, Carlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, Till Anselm UNSPECIFIED orcid.org/0000-0001-7023-146X UNSPECIFIED Pelzer, Esther Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-255014
DOI:	10.1016/j.neuroimage.2016.09.014
Journal or Publication Title:	Neuroimage
Volume:	143
Page Range:	S. 325 - 343
Date:	2016
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DYNAMIC CAUSAL-MODELS; PARKINSONS-DISEASE; PREMOTOR CORTEX; HEMISPHERIC-ASYMMETRY; INDUCED RESPONSES; NEURONAL-ACTIVITY; CEREBRAL-CORTEX; PACED MOVEMENT; FUNCTIONAL MRI; BRAIN Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25501