Warncke, K., Konrad, K., Kohne, E., Hammer, E., Ohlenschlaeger, U., Herrlinger, S., Jaeger, A. and Holl, R. W. (2016). Diabetes in Patients with ss-thalassemia or other Hemoglobinopathies - Analysis from the DPV Database. Klinische Padiatr., 228 (6-7). S. 307 - 313. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3824

Full text not available from this repository.

Abstract

Background: Diabetes mellitus is a common endocrinopathy in patients with thalassemia major, but the occurrence of hemoglobinopathies is rare in Germany and Western Europe. The longitudinal German-Austrian DPV (Diabetes Patienten Verlaufsdokumentation) registry allows a comprehensive characterization of this group of patients. Patients/methods: Patients from the DPV-registry aged<30 years with thalassemia major or other hemoglobinopathies were compared to patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) using the statistical software SAS 9.4. Results: 94 patients (0.13% of patients) with hemoglobinopathies are registered in DPV. 82.4% of 17 patients with thalassemia major, 100% of 12 patients with sickle cell disease (SCD) and >90% of 65 patients with other hemoglobinopathies receive insulin treatment. In the majority of patients with thalassemia major, hemosiderosis is documented. Patients with thalassemia major developed diabetes at a median age of 14.6 [IQR 8.4-18.0] years (9.0 years [5.3-12.5] in T1D; 18.7 years [14.2-25.6] in TD2; both p<0.01). They show high HbA1c/fructosamine levels and frequent hypoglycemia, reflecting poor metabolic control. Conclusion: Diabetes in thalassemia major is probably caused by hemosiderosis due to polytransfusion, while patients with SCD/thalassemia minor are most likely affected by T1D. The high rate of hypoglycemia in patients with ss-thalassemia major may be caused by liver fibrosis and a lack of hepatic glycogen stores.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Warncke, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konrad, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohne, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammer, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ohlenschlaeger, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrlinger, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holl, R. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-256800
DOI: 10.1055/s-0042-111691
Journal or Publication Title: Klinische Padiatr.
Volume: 228
Number: 6-7
Page Range: S. 307 - 313
Date: 2016
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1439-3824
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
METABOLIC-CONTROL; CHILDREN; GERMANY; MELLITUS; AUTOIMMUNITY; ADOLESCENTS; PREDICTION; ANEMIAMultiple languages
PediatricsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/25680

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item