Universität zu Köln

Baessler, Bettina ORCID: 0000-0002-3244-3864, Schaarschmidt, Frank, Stehning, Christian, Schnackenburg, Bernhard, Giolda, Agathe, Maintz, David and Bunck, Alexander C. (2016). Reproducibility of three different cardiac T-2-mapping sequences at 1.5T. J. Magn. Reson. Imaging, 44 (5). S. 1168 - 1179. HOBOKEN: WILEY. ISSN 1522-2586

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Abstract

PurposeTo elucidate the impact of technical and intraindividual reproducibility on the overall variability of myocardial T-2 relaxation times. Materials and MethodsThirty healthy volunteers were examined three times (day 1 morning/evening, evening after 2-3 weeks) at 1.5T. During each examination three different T-2-mapping sequences were acquired twice at three slices in short axis view: multi-echo-spin-echo (MESE), T-2-prepared balanced steady-state free precession (SSFP) (T(2)prep), and gradient-spin-echo with and without fat saturation (GraSE/GraSE(FS)). Repeated measurements were performed for T(2)prep and GraSE. Segmented T-2-maps were generated for each slice according to the American Heart Association (AHA) 16-segment model. ResultsThe coefficients of variation and intraclass correlation coefficients for intraobserver variability were: 1.3% and 0.89 for T(2)prep, 1.5% and 0.93 for GraSE, 3.1% and 0.83 for MESE; and for interobserver variability: 3.3% and 0.66 for T(2)prep, 2.0% and 0.83 for GraSE, 3.6% and 0.77 for MESE. No systematic difference of T-2 times was observed due to diurnal effects and on long-term analysis using one-way analysis of variance (ANOVA) with Tukey-type multiple comparisons (morning vs. evening scan for T(2)prep: 52.5 2.4 vs. 51.7 +/- 2.7 msec, P = 0.119; for GraSE: 58.6 +/- 4.0 vs. 58.5 +/- 3.8 msec, P = 0.984; for GraSE(FS) 57.1 +/- 3.2 vs. 57.2 +/- 3.9 msec, P = 0.998, and for MESE: 53.8 +/- 2.7 vs. 53.3 +/- 3.3 msec, P = 0.541; scans between weeks for T(2)prep: 51.7 +/- 2.7 vs. 51.4 +/- 2.4 msec, P = 0.873; for GraSE: 58.5 +/- 3.8 vs. 58.1 +/- 3.4 msec, P = 0.736; for GraSE(FS): 57.2 +/- 3.9 vs. 57.0 +/- 4.6 msec, P = 0.964, and for MESE: 53.3 +/- 3.3 vs. 53.4 +/- 2.4 msec, P = 0.970). ANOVA components, however, demonstrated a greater variance of T-2 times over multiple timepoints than for repeated measurements within the same scan (variance components of the model fit for intraday variance vs. repeated measurements: T(2)prep 2.22 vs. 1.36, GraSE 3.76 vs. 2.09, GraSE(FS) 3.96 vs. 1.58, MESE 1.86; and for interweeks variance vs. repeated measurements: T(2)prep 2.21 vs. 0.80, GraSE 3.20 vs. 2.10, GraSE(FS) 8.82 vs. 1.18, and MESE 4.49). ConclusionTechnical reproducibility and intra- and interobserver agreement of myocardial T-2 relaxation times are excellent and intraindividual variation over time is small. Therefore, we consider subject-related factors to explain most of the interindividual variability of myocardial T-2 times reported in previous studies. The acknowledgment of this subject-related, biological variability may be important for the future diagnostic value of T-2-mapping. J. Magn. Reson. Imaging 2016;44:1168-1178.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baessler, Bettina UNSPECIFIED orcid.org/0000-0002-3244-3864 UNSPECIFIED Schaarschmidt, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Stehning, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnackenburg, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Giolda, Agathe UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-256977
DOI:	10.1002/jmri.25258
Journal or Publication Title:	J. Magn. Reson. Imaging
Volume:	44
Number:	5
Page Range:	S. 1168 - 1179
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1522-2586
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYOCARDIAL EDEMA; T2 QUANTIFICATION; VARIABILITY; VOLUNTEERS; T-2 Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25697