Universität zu Köln

Pahlavian, Soroush Heidari, Bunck, Alexander C., Thyagaraj, Suraj, Giese, Daniel ORCID: 0000-0002-3925-4441, Loth, Francis, Hedderich, Dennis M., Kroeger, Jan Robert and Martin, Bryn A. ORCID: 0000-0003-1234-7880 (2016). Accuracy of 4D Flow Measurement of Cerebrospinal Fluid Dynamics in the Cervical Spine: An In Vitro Verification Against Numerical Simulation. Ann. Biomed. Eng., 44 (11). S. 3202 - 3215. NEW YORK: SPRINGER. ISSN 1573-9686

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Abstract

Abnormal alterations in cerebrospinal fluid (CSF) flow are thought to play an important role in pathophysiology of various craniospinal disorders such as hydrocephalus and Chiari malformation. Three directional phase contrast MRI (4D Flow) has been proposed as one method for quantification of the CSF dynamics in healthy and disease states, but prior to further implementation of this technique, its accuracy in measuring CSF velocity magnitude and distribution must be evaluated. In this study, an MR-compatible experimental platform was developed based on an anatomically detailed 3D printed model of the cervical subarachnoid space and subject specific flow boundary conditions. Accuracy of 4D Flow measurements was assessed by comparison of CSF velocities obtained within the in vitro model with the numerically predicted velocities calculated from a spatially averaged computational fluid dynamics (CFD) model based on the same geometry and flow boundary conditions. Good agreement was observed between CFD and 4D Flow in terms of spatial distribution and peak magnitude of through-plane velocities with an average difference of 7.5 and 10.6% for peak systolic and diastolic velocities, respectively. Regression analysis showed lower accuracy of 4D Flow measurement at the timeframes corresponding to low CSF flow rate and poor correlation between CFD and 4D Flow in-plane velocities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pahlavian, Soroush Heidari UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thyagaraj, Suraj UNSPECIFIED UNSPECIFIED UNSPECIFIED Giese, Daniel UNSPECIFIED orcid.org/0000-0002-3925-4441 UNSPECIFIED Loth, Francis UNSPECIFIED UNSPECIFIED UNSPECIFIED Hedderich, Dennis M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Jan Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Bryn A. UNSPECIFIED orcid.org/0000-0003-1234-7880 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-257041
DOI:	10.1007/s10439-016-1602-x
Journal or Publication Title:	Ann. Biomed. Eng.
Volume:	44
Number:	11
Page Range:	S. 3202 - 3215
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-9686
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NORMAL-PRESSURE HYDROCEPHALUS; PHASE-CONTRAST MR; RECONSTRUCTION; SYRINGOMYELIA; MALFORMATION; MODEL Multiple languages Engineering, Biomedical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25704