Universität zu Köln

Diegoli, Toni Marie, Rohde, Heinrich, Borowski, Stefan, Krawczak, Michael ORCID: 0000-0003-2603-1502, Coble, Michael D. and Nothnagel, Michael ORCID: 0000-0001-8305-7114 (2016). Genetic mapping of 15 human X chromosomal forensic short tandem repeat (STR) loci by means of multi-core parallelization. Forensic Sci. Int.-Genet., 25. S. 39 - 45. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-0326

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Abstract

Typing of X chromosomal short tandem repeat (X STR) markers has become a standard element of human forensic genetic analysis. Joint consideration of many X STR markers at a time increases their discriminatory power but, owing to physical linkage, requires inter-marker recombination rates to be accurately known. We estimated the recombination rates between 15 well established X STR markers using genotype data from 158 families (1041 individuals) and following a previously proposed likelihoodbased approach that allows for single-step mutations. To meet the computational requirements of this family-based type of analysis, we modified a previous implementation so as to allow multi-core parallelization on a high-performance computing system. While we obtained recombination rate estimates larger than zero for all but one pair of adjacent markers within the four previously proposed linkage groups, none of the three X STR pairs defining the junctions of these groups yielded a recombination rate estimate of 0.50. Corroborating previous studies, our results therefore argue against a simple model of independent X chromosomal linkage groups. Moreover, the refined recombination fraction estimates obtained in our study will facilitate the appropriate joint consideration of all 15 investigated markers in forensic analysis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Diegoli, Toni Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohde, Heinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Borowski, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Krawczak, Michael UNSPECIFIED orcid.org/0000-0003-2603-1502 UNSPECIFIED Coble, Michael D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nothnagel, Michael UNSPECIFIED orcid.org/0000-0001-8305-7114 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-257745
DOI:	10.1016/j.fsigen.2016.07.004
Journal or Publication Title:	Forensic Sci. Int.-Genet.
Volume:	25
Page Range:	S. 39 - 45
Date:	2016
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1878-0326
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POPULATION-DATA; PCR SYSTEM; MARKERS; REGION; RECOMBINATION; LINKAGE; ASSAY Multiple languages Genetics & Heredity; Medicine, Legal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25774