Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Presmanes, Eduardo Cebollero, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria ORCID: 0000-0003-0546-8764, Galli, Carmela, Loi, Marisa ORCID: 0000-0002-9186-8379, Solda, Tatiana, D'Antuono, Rocco ORCID: 0000-0003-0180-6500, Raimondi, Andrea ORCID: 0000-0002-4563-386X, Jung, Martin ORCID: 0000-0002-1482-7020, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne ORCID: 0000-0001-6766-2808, Simonelli, Luca ORCID: 0000-0001-6331-7716, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay ORCID: 0000-0002-2289-9083, Peter, Matthias ORCID: 0000-0002-2160-6824, Quadroni, Manfredo ORCID: 0000-0002-2720-4084, Zimmermann, Richard and Molinari, Maurizio ORCID: 0000-0002-7636-5829 (2016). Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. Nat. Cell Biol., 18 (11). S. 1173 - 1199. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4679

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Abstract

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzymes to reduce the burden of misfolded proteins. On resolution of ER stress, ill-defined, selective autophagic programs remove excess ER components. Here we identify Sec62, a constituent of the translocon complex regulating protein import in the mammalian ER, as an ER-resident autophagy receptor. Sec62 intervenes during recovery from ER stress to selectively deliver ER components to the autolysosomal system for clearance in a series of events that we name recovER-phagy. Sec62 contains a conserved LC3-interacting region in the C-terminal cytosolic domain that is required for its function in recovER-phagy, but is dispensable for its function in the protein translocation machinery. Our results identify Sec62 as a critical molecular component in maintenance and recovery of ER homeostasis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fumagalli, FiorenzaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noack, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergmann, Timothy J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Presmanes, Eduardo CebolleroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pisoni, Giorgia BrambillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fasana, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fregno, IlariaUNSPECIFIEDorcid.org/0000-0003-0546-8764UNSPECIFIED
Galli, CarmelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loi, MarisaUNSPECIFIEDorcid.org/0000-0002-9186-8379UNSPECIFIED
Solda, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Antuono, RoccoUNSPECIFIEDorcid.org/0000-0003-0180-6500UNSPECIFIED
Raimondi, AndreaUNSPECIFIEDorcid.org/0000-0002-4563-386XUNSPECIFIED
Jung, MartinUNSPECIFIEDorcid.org/0000-0002-1482-7020UNSPECIFIED
Melnyk, ArminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schorr, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreiber, AnneUNSPECIFIEDorcid.org/0000-0001-6766-2808UNSPECIFIED
Simonelli, LucaUNSPECIFIEDorcid.org/0000-0001-6331-7716UNSPECIFIED
Varani, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilson-Zbinden, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zerbe, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofmann, KayUNSPECIFIEDorcid.org/0000-0002-2289-9083UNSPECIFIED
Peter, MatthiasUNSPECIFIEDorcid.org/0000-0002-2160-6824UNSPECIFIED
Quadroni, ManfredoUNSPECIFIEDorcid.org/0000-0002-2720-4084UNSPECIFIED
Zimmermann, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molinari, MaurizioUNSPECIFIEDorcid.org/0000-0002-7636-5829UNSPECIFIED
URN: urn:nbn:de:hbz:38-257907
DOI: 10.1038/ncb3423
Journal or Publication Title: Nat. Cell Biol.
Volume: 18
Number: 11
Page Range: S. 1173 - 1199
Date: 2016
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-4679
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SELECTIVE AUTOPHAGY; MAMMALIAN-CELLS; QUALITY-CONTROL; ER; DEGRADATION; PROTEINS; CANCER; AMPLIFICATION; MECHANISMS; REGULATORSMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/25790

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