Universität zu Köln

Thevis, Mario, Geyer, Hans, Tretzel, Laura and Schaezer, Wilhelm (2016). Sports drug testing using complementary matrices: Advantages and limitations. J. Pharm. Biomed. Anal., 130. S. 220 - 231. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-264X

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Abstract

Today, routine doping controls largely rely on testing whole blood, serum, and urine samples. These matrices allow comprehensively covering inorganic as well as low and high molecular mass organic analytes relevant to doping controls and are collecting and transferring from sampling sites to accredited anti doping laboratories under standardized conditions. Various aspects including time and cost-effectiveness as well as intrusiveness and invasiveness of the sampling procedure but also analyte stability and breadth of the contained information have been motivation to consider and assess values potentially provided and added to modern sports drug testing programs by alternative matrices. Such alternatives could be dried blood spots (DBS), dried plasma spots (DPS), oral fluid (OF), exhaled breath (EB), and hair. In this review, recent developments and test methods concerning these alternative matrices and expected or proven contributions as well as limitations of these specimens in the context of the international anti-doping fight are presented and discussed, guided by current regulations for prohibited substances and methods of doping as established by the World Anti-Doping Agency (WADA). Focusing on literature published between 2011 and 2015, examples for doping control analytical assays concerning non-approved substances, anabolic agents, peptide hormones/growth factors/related substances and mimetics, beta(2)-agonists, hormone and metabolic modulators, diuretics and masking agents, stimulants, narcotics, cannabinoids, glucocorticoids, and beta-blockers were selected to outline the advantages and limitations of the aforementioned alternative matrices as compared to conventional doping control samples (Le. urine and blood/serum). (C) 2016 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Tretzel, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaezer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258171
DOI:	10.1016/j.jpba.2016.03.055
Journal or Publication Title:	J. Pharm. Biomed. Anal.
Volume:	130
Page Range:	S. 220 - 231
Date:	2016
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1873-264X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRIED BLOOD SPOTS; TANDEM MASS-SPECTROMETRY; DOPING CONTROL ANALYSIS; PERFORMANCE LIQUID-CHROMATOGRAPHY; ANABOLIC-STEROID ESTERS; SOLID-PHASE EXTRACTION; SIRT1 ACTIVATING DRUGS; LONG-TERM MARKERS; LC-MS-MS; ORAL FLUID Multiple languages Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25817