Universität zu Köln

Fedorchenko, Oleg, Rosen, Natascha, Koch, Maximilian, Barthel, Romy, Winarski, Tomasz, Florin, Alexandra, Wunderlich, F. Thomas, Reinart, Nina and Hallek, Michael (2016). LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia. Cancer Cell, 30 (4). S. 610 - 623. CAMBRIDGE: CELL PRESS. ISSN 1878-3686

Full text not available from this repository.

Abstract

Survival of chronic lymphocytic leukemia (CLL) cells strictly depends on the support of an appropriate tumor microenvironment. Here, we demonstrate that LYN kinase is essential for CLL progression. Lyn deficiency results in a significantly reduced CLL burden in vivo. Loss of Lyn within leukemic cells reduces B cell receptor (BCR) signaling including BTK phosphorylation, but surprisingly does not affect leukemic cell expansion. Instead, syngeneic CLL transplantation of CLL cells into Lyn- or Btk-deficient recipients results in a strongly delayed leukemic progression and prolonged survival. Moreover, Lyn deficiency in macrophages hinders nursing functions for CLL cells, which is mediated by direct contact rather than secretion of soluble factors. Taken together, LYN and BTK seem essential for the formation of a microenvironment supporting leukemic growth.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fedorchenko, Oleg UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Natascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Barthel, Romy UNSPECIFIED UNSPECIFIED UNSPECIFIED Winarski, Tomasz UNSPECIFIED UNSPECIFIED UNSPECIFIED Florin, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunderlich, F. Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinart, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258463
DOI:	10.1016/j.ccell.2016.09.007
Journal or Publication Title:	Cancer Cell
Volume:	30
Number:	4
Page Range:	S. 610 - 623
Date:	2016
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1878-3686
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; BRUTONS TYROSINE KINASE; SRC-FAMILY KINASES; DEFICIENT MICE; IN-VIVO; DISEASE DEVELOPMENT; AUTOIMMUNE-DISEASE; SIGNALING PATHWAYS; PHASE-II; CELLS Multiple languages Oncology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25846