Universität zu Köln

Peters, Jan ORCID: 0000-0002-0195-5357 and D'Esposito, Mark (2016). Effects of Medial Orbitofrontal Cortex Lesions on Self-Control in Intertemporal Choice. Curr. Biol., 26 (19). S. 2625 - 2629. CAMBRIDGE: CELL PRESS. ISSN 1879-0445

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Abstract

Many decisions involve a trade-off between the temporal proximity of a reward and its magnitude. A range of clinical conditions are associated with poor self-control during such intertemporal choices, such that smaller rewards that are received sooner are preferred over larger rewards that are received later to a greater extent [1, 2]. According to a prominent neural model of self-control [3-6], subjective reward values are represented in the medial orbitofrontal cortex (mOFC) at the time of choice [7-9]. Successful self-control in this model is then thought to depend on a modulation of these mOFC value representations via the lateral prefrontal cortex (IPFC) [3, 6]. Here we directly tested three key predictions of this model in patients with lesions to the mOFC (n = 9) and matched controls (n = 19). First, we show that mOFC lesions disrupt choice-free valuation ratings. This finding provides causal evidence for a role of the mOFC in reward valuation and contrasts with the effects of IPFC disruption [6]. Second, we show that mOFC damage indeed decreases self-control during intertemporal choice, replicating previous findings [10]. Third, extending these previous observations, we show that the effect of mOFC damage on intertemporal choice depends on the actual self-control demands of the task. Our findings thus provide causal evidence for a role of mOFC in reward valuation and are compatible with the idea that mOFC damage affects self-control specifically under conditions that might normally require a modulation of mOFC value representations, e.g., by the IPFC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Peters, Jan UNSPECIFIED orcid.org/0000-0002-0195-5357 UNSPECIFIED D'Esposito, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258475
DOI:	10.1016/j.cub.2016.07.035
Journal or Publication Title:	Curr. Biol.
Volume:	26
Number:	19
Page Range:	S. 2625 - 2629
Date:	2016
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1879-0445
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREFRONTAL CORTEX; DECISION-MAKING; NEURAL MECHANISMS; VALUATION SYSTEM; SUBJECTIVE VALUE; FUTURE REWARDS; HUMANS; VMPFC Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25847