Peters, Jan ORCID: 0000-0002-0195-5357 and D'Esposito, Mark (2016). Effects of Medial Orbitofrontal Cortex Lesions on Self-Control in Intertemporal Choice. Curr. Biol., 26 (19). S. 2625 - 2629. CAMBRIDGE: CELL PRESS. ISSN 1879-0445
Full text not available from this repository.Abstract
Many decisions involve a trade-off between the temporal proximity of a reward and its magnitude. A range of clinical conditions are associated with poor self-control during such intertemporal choices, such that smaller rewards that are received sooner are preferred over larger rewards that are received later to a greater extent [1, 2]. According to a prominent neural model of self-control [3-6], subjective reward values are represented in the medial orbitofrontal cortex (mOFC) at the time of choice [7-9]. Successful self-control in this model is then thought to depend on a modulation of these mOFC value representations via the lateral prefrontal cortex (IPFC) [3, 6]. Here we directly tested three key predictions of this model in patients with lesions to the mOFC (n = 9) and matched controls (n = 19). First, we show that mOFC lesions disrupt choice-free valuation ratings. This finding provides causal evidence for a role of the mOFC in reward valuation and contrasts with the effects of IPFC disruption [6]. Second, we show that mOFC damage indeed decreases self-control during intertemporal choice, replicating previous findings [10]. Third, extending these previous observations, we show that the effect of mOFC damage on intertemporal choice depends on the actual self-control demands of the task. Our findings thus provide causal evidence for a role of mOFC in reward valuation and are compatible with the idea that mOFC damage affects self-control specifically under conditions that might normally require a modulation of mOFC value representations, e.g., by the IPFC.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-258475 | ||||||||||||
DOI: | 10.1016/j.cub.2016.07.035 | ||||||||||||
Journal or Publication Title: | Curr. Biol. | ||||||||||||
Volume: | 26 | ||||||||||||
Number: | 19 | ||||||||||||
Page Range: | S. 2625 - 2629 | ||||||||||||
Date: | 2016 | ||||||||||||
Publisher: | CELL PRESS | ||||||||||||
Place of Publication: | CAMBRIDGE | ||||||||||||
ISSN: | 1879-0445 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/25847 |
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