Universität zu Köln

Kakanj, Parisa, Moussian, Bernard, Groenke, Sebastian, Bustos, Victor ORCID: 0000-0002-2251-8295, Eming, Sabine A., Partridge, Linda ORCID: 0000-0001-9615-0094 and Leptin, Maria ORCID: 0000-0001-7097-348X (2016). Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nat. Commun., 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

The TOR and Insulin/IGF signalling (IIS) network controls growth, metabolism and ageing. Although reducing TOR or insulin signalling can be beneficial for ageing, it can be detrimental for wound healing, but the reasons for this difference are unknown. Here we show that IIS is activated in the cells surrounding an epidermal wound in Drosophila melanogaster larvae, resulting in PI3K activation and redistribution of the transcription factor FOXO. Insulin and TOR signalling are independently necessary for normal wound healing, with FOXO and S6K as their respective effectors. IIS is specifically required in cells surrounding the wound, and the effect is independent of glycogen metabolism. Insulin signalling is needed for the efficient assembly of an actomyosin cable around the wound, and constitutively active myosin II regulatory light chain suppresses the effects of reduced IIS. These findings may have implications for the role of insulin signalling and FOXO activation in diabetic wound healing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kakanj, Parisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Moussian, Bernard UNSPECIFIED UNSPECIFIED UNSPECIFIED Groenke, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bustos, Victor UNSPECIFIED orcid.org/0000-0002-2251-8295 UNSPECIFIED Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Partridge, Linda UNSPECIFIED orcid.org/0000-0001-9615-0094 UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258526
DOI:	10.1038/ncomms12972
Journal or Publication Title:	Nat. Commun.
Volume:	7
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DROSOPHILA-MELANOGASTER; LIFE-SPAN; EXPRESSION; CLOSURE; DFOXO; SKIN; MTOR; PHOSPHORYLATION; DIFFERENTIATION; ORCHESTRATE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25852