Universität zu Köln

Matucci-Cerinic, Marco, Krieg, Thomas, Guillevin, Loic, Schwierin, Barbara, Rosenberg, Daniel, Cornelisse, Peter and Denton, Christopher P. (2016). Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry. Ann. Rheum. Dis., 75 (10). S. 1770 - 1777. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2060

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Abstract

Objectives Digital ulcers (DUs) occur in up to half of patients with systemic sclerosis (SSc) and may lead to infection, gangrene and amputation with functional disability and reduced quality of life. This study has elucidated the burden of SSc-associated DUs through identification of four patient categories based on the pattern of DU recurrence over a 2-year observation period. Methods Patients with SSc-associated DUs enrolled in the Digital Ulcers Outcome Registry between 1 April 2008 and 19 November 2013, and with 2years of observation and 3 follow-up visits during the observation period were analysed. Incident DU-associated complications were recorded during follow-up. Work and daily activity impairment were measured using a functional assessment questionnaire completed by patients after the observation period. Potential factors that could predict incident complications were identified in patients with chronic DUs. Results From 1459 patients, four DU occurrence categories were identified: 33.2% no-DU; 9.4% episodic; 46.2% recurrent; 11.2% chronic. During the observation period, patients from the chronic category had the highest rate of incident complications, highest work impairment and greatest need for help compared with the other categories. Independent factors associated with incident complications included gastrointestinal manifestations (OR 3.73, p=0.03) and previous soft tissue infection (OR 5.86, p=0.01). Conclusions This proposed novel categorisation of patients with SSc-associated DUs based on the occurrence of DUs over time may help to identify patients in the clinic with a heavier DU burden who could benefit from more complex management to improve their functioning and quality of life.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Matucci-Cerinic, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Guillevin, Loic UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwierin, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenberg, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornelisse, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Denton, Christopher P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-260848
DOI:	10.1136/annrheumdis-2015-208121
Journal or Publication Title:	Ann. Rheum. Dis.
Volume:	75
Number:	10
Page Range:	S. 1770 - 1777
Date:	2016
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2060
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK-FACTORS; SCLERODERMA; DISEASE; DATABASE Multiple languages Rheumatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26084