Universität zu Köln

Suchorska, B., Hamisch, C., Treuer, H., Mahnkopf, K., Lehrke, R. E., Kocher, M., Ruge, M. I. and Voges, J. (2016). Stereotactic brachytherapy using iodine 125 seeds for the treatment of primary and recurrent anaplastic glioma WHOA degrees III. J. Neuro-Oncol., 130 (1). S. 123 - 132. NEW YORK: SPRINGER. ISSN 1573-7373

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Abstract

The current study analyzed the outcome after stereotactic brachytherapy (SBT) using iodine-125 seeds in anaplastic astrocytoma, oligoastrocytoma or oligodendroglioma not suitable for resection. Out of 223 patients harbouring a malignant glioma treated according to a prospective protocol, 172 patients were selected who received SBT to treat a WHO grade III de-novo/residual tumor (n = 99) or a tumor recurrence after multimodal treatment (n = 73). We assessed progression free survival (PFS), overall survival (OS), radiological and clinical outcome and determined prognostic factors using univariate and multivariate regression analyses. The median follow-up time was 38 months. Median OS and median PFS was 28.9 and 21.4 months in the de-novo group vs. 49.4 and 32.6 months in the recurrence group. Recurrent tumors had more frequently (p = 0.01) an oligodendroglial-component compared to de novo tumors. According to cohort-specific univariate analyses KPS at SBT had a significant (p = 0.008) impact on OS in the de-novo group. In the recurrence group, (Cox regression analysis) OS was significantly associated with histology subtype (oligoastro-/oligodendroglioma vs. astrocytoma, p = 0.043). Transient and permanent morbidity (similar to 1 %) was low. For patients unable to undergo surgery due to eloquent tumour location or reduced general condition SBT is an effective treatment option, which does not foreclose additional therapeutic interventions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Suchorska, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamisch, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Treuer, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahnkopf, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehrke, R. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kocher, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruge, M. I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Voges, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-261640
DOI:	10.1007/s11060-016-2214-x
Journal or Publication Title:	J. Neuro-Oncol.
Volume:	130
Number:	1
Page Range:	S. 123 - 132
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-7373
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-GRADE GLIOMAS; MALIGNANT GLIOMAS; RADIATION-THERAPY; INTERSTITIAL BRACHYTHERAPY; I-125 BRACHYTHERAPY; PROGNOSTIC-FACTORS; CEREBRAL GLIOMAS; GLIOBLASTOMA; RADIOSURGERY; RADIOTHERAPY Multiple languages Oncology; Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26164