Universität zu Köln

Florea, Florina, Koch, Manuel, Hashimoto, Takashi ORCID: 0000-0002-0144-3255 and Sitaru, Cassian ORCID: 0000-0002-0370-1270 (2016). Autoimmunity against laminins. Clin. Immunol., 170. S. 39 - 53. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1521-7035

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Abstract

Laminins are ubiquitous constituents of the basement membranes with major architectural and functional role as supported by the fact that absence or mutations of laminins lead to either lethal or severely impairing phenotypes. Besides genetic defects, laminins are involved in a wide range of human diseases including cancer, infections, and inflammatory diseases, as well as autoimmune disorders. A growing body of evidence implicates several laminin chains as autoantigens in blistering skin diseases, collagenoses, vasculitis, or post-infectious autoimmunity. The current paper reviews the existing knowledge on autoimmunity against laminins referring to both experimental and clinical data, and on therapeutic implications of anti-laminin antibodies. Further investigation of relevant laminin epitopes in pathogenic autoimmunity would facilitate the development of appropriate diagnostic tools for thorough characterization of patients' antibody specificities and should decisively contribute to designing more specific therapeutic interventions. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Florea, Florina UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hashimoto, Takashi UNSPECIFIED orcid.org/0000-0002-0144-3255 UNSPECIFIED Sitaru, Cassian UNSPECIFIED orcid.org/0000-0002-0370-1270 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-264323
DOI:	10.1016/j.clim.2016.07.021
Journal or Publication Title:	Clin. Immunol.
Volume:	170
Page Range:	S. 39 - 53
Date:	2016
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1521-7035
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBEPIDERMAL BLISTERING DISEASE; GLOMERULAR-BASEMENT-MEMBRANE; JUNCTIONAL EPIDERMOLYSIS-BULLOSA; CUTANEOUS LUPUS-ERYTHEMATOSUS; CONGENITAL MUSCULAR-DYSTROPHY; LINKED-IMMUNOSORBENT-ASSAY; ADULT-MOUSE TISSUES; MUCOUS-MEMBRANE; VII COLLAGEN; IGG AUTOANTIBODIES Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26432