Universität zu Köln

Zischler, Johannes ORCID: 0000-0003-3996-7473, Krapf, Philipp ORCID: 0000-0003-1671-2443, Richarz, Raphael, Zlatopolskiy, Boris D. and Neumaier, Bernd ORCID: 0000-0001-5425-3116 (2016). Automated synthesis of 4-[F-18]fluoroanisole, [F-18]DAA1106 and 4-[F-18]FPhe using Cu-mediated radiofluorination under minimalist conditions. Appl. Radiat. Isot., 115. S. 133 - 138. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 0969-8043

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Abstract

The application of the minimalist approach to Cu-mediated radiofluorination allows the efficient preparation of F-18-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabled the automated production of 4-[F-18]fluoroanisole as well as the clinically relevant PET-tracers, 4-[F-18]FPhe and [F-18]DAA1106, in radiochemical yields of 41-61% and radiochemical purities of > 95% within 30-60 min. These results demonstrated the high efficacy and versatility of the developed method that will open up opportunities for a broad application of Cu-mediated radiofluorination in PET-chemistry. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zischler, Johannes UNSPECIFIED orcid.org/0000-0003-3996-7473 UNSPECIFIED Krapf, Philipp UNSPECIFIED orcid.org/0000-0003-1671-2443 UNSPECIFIED Richarz, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Zlatopolskiy, Boris D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-264911
DOI:	10.1016/j.apradiso.2016.04.030
Journal or Publication Title:	Appl. Radiat. Isot.
Volume:	115
Page Range:	S. 133 - 138
Date:	2016
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	0969-8043
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERIPHERAL BENZODIAZEPINE-RECEPTORS; PET; SALTS; TSPO Multiple languages Chemistry, Inorganic & Nuclear; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26491