Universität zu Köln

Kreppel, Matthias, Safi, Ali-Farid, Scheer, Martin, Nickenig, Hans-Joachim, Zoeller, Joachim, Preuss, Simon, Meyer, Moritz, Rothamel, Daniel and Dreiseidler, Timo (2016). The importance of early diagnosis in patients with maxillary sinus carcinoma. Eur. Arch. Oto-Rhino-Laryn., 273 (9). S. 2629 - 2636. NEW YORK: SPRINGER. ISSN 1434-4726

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Abstract

There are two major challenges in the early diagnosis of maxillary sinus carcinoma: the maxillary sinus is not susceptible to direct inspection and palpation, and symptoms are uncharacteristic. The aim of this study was to assess the impact of the time interval between first symptoms noticed by the patient and the detection of the tumor on survival. 88 patients with maxillary sinus tumors were included in the retrospective study. Prognostic factors were identified through univariate analysis. Univariate analysis (p = 0.019) revealed a significant impact of the time interval from first symptom to diagnosis on overall survival. With increasing duration of the symptoms 5-year overall survival was reduced from 65 % for duration between 0 and 2 months to 24 % for duration of symptoms longer than 12 months. Furthermore, we found a significant association (p = 0.033) between local extension of the tumor and time interval from first symptom to diagnosis. Early diagnosis is often difficult because of uncharacteristic symptoms, which are identical with benign diseases of the maxillary sinus. The delay between the occurrence of the first symptom and diagnosis often makes a curative treatment impossible.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Preuss, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreiseidler, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-265159
DOI:	10.1007/s00405-015-3776-5
Journal or Publication Title:	Eur. Arch. Oto-Rhino-Laryn.
Volume:	273
Number:	9
Page Range:	S. 2629 - 2636
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1434-4726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTERIOR SKULL BASE; SINGLE INSTITUTION EXPERIENCE; EPITHELIAL OVARIAN-CANCER; SQUAMOUS-CELL CARCINOMA; PARANASAL SINUSES; NASAL CAVITY; MALIGNANT-TUMORS; CRANIOFACIAL RESECTION; RETROSPECTIVE ANALYSIS; PROGNOSTIC-FACTORS Multiple languages Otorhinolaryngology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26515