Franko, Andras ORCID: 0000-0003-0485-5439, Huypens, Peter ORCID: 0000-0001-7922-5787, Neschen, Susanne, Irmler, Martin, Rozman, Jan ORCID: 0000-0002-8035-8904, Rathkolb, Birgit, Neff, Frauke, Prehn, Cornelia ORCID: 0000-0002-1274-4715, Dubois, Guillaume, Baumann, Martina, Massinger, Rebecca, Gradinger, Daniel, Przemeck, Gerhard K. H. ORCID: 0000-0003-3730-3454, Repp, Birgit, Aichler, Michaela, Feuchtinger, Annette, Schommers, Philipp ORCID: 0000-0003-3375-6800, Stoehr, Oliver, Sanchez-Lasheras, Carmen, Adamski, Jerzy ORCID: 0000-0001-9259-0199, Peter, Andreas, Prokisch, Holger ORCID: 0000-0003-2379-6286, Beckers, Johannes ORCID: 0000-0001-7874-3822, Walch, Axel K., Fuchs, Helmut, Wolf, Eckhard ORCID: 0000-0002-0430-9510, Schubert, Markus, Wiesner, Rudolf J. and de Angelis, Martin Hrabe ORCID: 0000-0002-7898-2353 (2016). Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice. Diabetes, 65 (9). S. 2540 - 2553. ALEXANDRIA: AMER DIABETES ASSOC. ISSN 1939-327X

Full text not available from this repository.

Abstract

Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), has been generally used to treat hyperlipidemia for decades. Clinical trials with type 2 diabetes patients indicated that BEZ also has beneficial effects on glucose metabolism, although the underlying mechanisms of these effects remain elusive. Even less is known about a potential role for BEZ in treating type 1 diabetes. Here we show that BEZ markedly improves hyperglycemia and glucose and insulin tolerance in mice with streptozotocin (STZ)-induced diabetes, an insulin-deficient mouse model of type 1 diabetes. BEZ treatment of STZ mice significantly suppressed the hepatic expression of genes that are annotated in inflammatory processes, whereas the expression of PPAR and insulin target gene transcripts was increased. Furthermore, BEZ-treated mice also exhibited improved metabolic flexibility as well as an enhanced mitochondria! mass and function in the liver. Finally, we show that the number of pancreatic islets and the area of insulin-positive cells tended to be higher in BEZ-treated mice. Our data suggest that BEZ may improve impaired glucose metabolism by augmenting hepatic mitochondria) performance, suppressing hepatic inflammatory pathways, and improving insulin sensitivity and metabolic flexibility. Thus, BEZ treatment might also be useful for patients with impaired glucose tolerance or diabetes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Franko, AndrasUNSPECIFIEDorcid.org/0000-0003-0485-5439UNSPECIFIED
Huypens, PeterUNSPECIFIEDorcid.org/0000-0001-7922-5787UNSPECIFIED
Neschen, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Irmler, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rozman, JanUNSPECIFIEDorcid.org/0000-0002-8035-8904UNSPECIFIED
Rathkolb, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neff, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prehn, CorneliaUNSPECIFIEDorcid.org/0000-0002-1274-4715UNSPECIFIED
Dubois, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumann, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Massinger, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gradinger, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Przemeck, Gerhard K. H.UNSPECIFIEDorcid.org/0000-0003-3730-3454UNSPECIFIED
Repp, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aichler, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feuchtinger, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schommers, PhilippUNSPECIFIEDorcid.org/0000-0003-3375-6800UNSPECIFIED
Stoehr, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Lasheras, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adamski, JerzyUNSPECIFIEDorcid.org/0000-0001-9259-0199UNSPECIFIED
Peter, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prokisch, HolgerUNSPECIFIEDorcid.org/0000-0003-2379-6286UNSPECIFIED
Beckers, JohannesUNSPECIFIEDorcid.org/0000-0001-7874-3822UNSPECIFIED
Walch, Axel K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, EckhardUNSPECIFIEDorcid.org/0000-0002-0430-9510UNSPECIFIED
Schubert, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiesner, Rudolf J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Angelis, Martin HrabeUNSPECIFIEDorcid.org/0000-0002-7898-2353UNSPECIFIED
URN: urn:nbn:de:hbz:38-265482
DOI: 10.2337/db15-1670
Journal or Publication Title: Diabetes
Volume: 65
Number: 9
Page Range: S. 2540 - 2553
Date: 2016
Publisher: AMER DIABETES ASSOC
Place of Publication: ALEXANDRIA
ISSN: 1939-327X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MITOCHONDRIAL MYOPATHY; RESPIRATORY-CHAIN; BETA-OXIDATION; GLUCOSE; ACTIVATION; LIVER; DEFICIENCY; RESISTANCE; LIPIDS; HYPERTRIGLYCERIDEMIAMultiple languages
Endocrinology & MetabolismMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26548

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item