Universität zu Köln

Niess, Hanno, Thomas, Michael N., Schiergens, Tobias S., Kleespies, Axel, Jauch, Karl-Walter, Bruns, Christiane, Werner, Jens, Nelson, Peter J. and Angele, Martin K. (2016). Genetic engineering of mesenchymal stromal cells for cancer therapy: turning partners in crime into Trojan horses. Innov. Surg. Sci., 1 (1). S. 19 - 33. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2364-7485

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Abstract

Mesenchymal stromal cells (MSCs) are adult progenitor cells with a high migratory and differentiation potential, which influence a broad range of biological functions in almost every tissue of the body. Among other mechanisms, MSCs do so by the secretion of molecular cues, differentiation toward more specialized cell types, or influence on the immune system. Expanding tumors also depend on the contribution of MSCs to building a supporting stroma, but the effects of MSCs appear to go beyond the mere supply of connective tissues. MSCs show targeted homing toward growing tumors, which is then followed by exerting direct and indirect effects on cancer cells. Several research groups have developed novel strategies that make use of the tumor tropism of MSCs by engineering them to express a transgene that enables an attack on cancer growth. This review aims to familiarize the reader with the current knowledge about MSC biology, the existing evidence for MSC contribution to tumor growth with its underlying mechanisms, and the strategies that have been developed using MSCs to deploy an anticancer therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Niess, Hanno UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Michael N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiergens, Tobias S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleespies, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Jauch, Karl-Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelson, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Angele, Martin K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-265632
DOI:	10.1515/iss-2016-0005
Journal or Publication Title:	Innov. Surg. Sci.
Volume:	1
Number:	1
Page Range:	S. 19 - 33
Date:	2016
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2364-7485
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SODIUM-IODIDE SYMPORTER; MOUSE XENOGRAFT MODEL; HUMAN ADIPOSE-TISSUE; STEM-CELLS; TUMOR STROMA; PROGENITOR CELLS; LYMPHOCYTE-PROLIFERATION; IN-VITRO; CHEMOKINE RECEPTORS; EXPRESSION Multiple languages Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26563