Leibovici, Leonard, Paul, Mical, Garner, Paul ORCID: 0000-0002-0607-6941, Sinclair, David J., Afshari, Arash, Pace, Nathan Leon, Cullum, Nicky ORCID: 0000-0003-2631-123X, Williams, Hywel C., Smyth, Alan ORCID: 0000-0001-5494-5438, Skoetz, Nicole, Del Mar, Chris ORCID: 0000-0003-3821-8163, Schilder, Anne G. M., Yahav, Dafna ORCID: 0000-0003-3181-9791 and Tovey, David (2016). Addressing resistance to antibiotics in systematic reviews of antibiotic interventions. J. Antimicrob. Chemother., 71 (9). S. 2367 - 2370. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

Full text not available from this repository.

Abstract

Antibiotics are among the most important interventions in healthcare. Resistance of bacteria to antibiotics threatens the effectiveness of treatment. Systematic reviews of antibiotic treatments often do not address resistance to antibiotics even when data are available in the original studies. This omission creates a skewed view, which emphasizes short-term efficacy and ignores the long-term consequences to the patient and other people. We offer a framework for addressing antibiotic resistance in systematic reviews. We suggest that the data on background resistance in the original trials should be reported and taken into account when interpreting results. Data on emergence of resistance (whether in the body reservoirs or in the bacteria causing infection) are important outcomes. Emergence of resistance should be taken into account when interpreting the evidence on antibiotic treatment in randomized controlled trials or systematic reviews.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Leibovici, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, MicalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garner, PaulUNSPECIFIEDorcid.org/0000-0002-0607-6941UNSPECIFIED
Sinclair, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Afshari, ArashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pace, Nathan LeonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cullum, NickyUNSPECIFIEDorcid.org/0000-0003-2631-123XUNSPECIFIED
Williams, Hywel C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smyth, AlanUNSPECIFIEDorcid.org/0000-0001-5494-5438UNSPECIFIED
Skoetz, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Mar, ChrisUNSPECIFIEDorcid.org/0000-0003-3821-8163UNSPECIFIED
Schilder, Anne G. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yahav, DafnaUNSPECIFIEDorcid.org/0000-0003-3181-9791UNSPECIFIED
Tovey, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-265663
DOI: 10.1093/jac/dkw135
Journal or Publication Title: J. Antimicrob. Chemother.
Volume: 71
Number: 9
Page Range: S. 2367 - 2370
Date: 2016
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2091
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRIALMultiple languages
Infectious Diseases; Microbiology; Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26566

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item