Universität zu Köln

Kendel, Friederike, Helbig, Lukas, Neumann, Konrad, Herden, Jan ORCID: 0000-0002-1667-5200, Stephan, Carsten, Schrader, Mark and Gaissmaier, Wolfgang (2016). Patients' perceptions of mortality risk for localized prostate cancer vary markedly depending on their treatment strategy. Int. J. Cancer, 139 (4). S. 749 - 754. HOBOKEN: WILEY. ISSN 1097-0215

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Abstract

Treatment choice for localized prostate cancer (PCa) is a controversial issue, and mortality risk is probably the most decisive factor in this regard. The study aimed to compare prostate-cancer-specific mortality risk estimates for different treatment options assigned by patients managed with active surveillance (AS), radical prostatectomy (RP) and patients who had discontinued AS (DAS). Patients initially managed with AS or RP (N = 370) were matched according to length of therapy. All patients completed mailed questionnaires assessing their mortality risk estimates (in %) and prostate-cancer-specific anxiety. Differences in risk estimates among the three treatment groups were analyzed using ANOVA, relationships of clinical and psychosocial variables with risk estimates using standard multiple regression. In all treatment groups, the prostate-cancer-specific mortality risk was overestimated. This applied whether it was the patient's own treatment or the alternative treatment option. RP patients assigned a mortality risk to AS that was almost three times higher than that assigned to RP (50.9 +/- 25.0 vs. 17.8 +/- 19.7, d = 1.48; p < 0.001). Anxiety was significantly associated with risk estimates for AS (p = 0.008) and RP (p = 0.001). Compared with clinical data that suggest that the prostate-cancer-specific mortality risk for AS is low and does not significantly differ from that for RP, patients strongly overestimated the mortality risk. This was most markedly so in RP patients, who drastically overestimated the benefits of RP compared to the risk of AS. This overestimation could increase overtreatment and should therefore be corrected by better patient education.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kendel, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Helbig, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Konrad UNSPECIFIED UNSPECIFIED UNSPECIFIED Herden, Jan UNSPECIFIED orcid.org/0000-0002-1667-5200 UNSPECIFIED Stephan, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schrader, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaissmaier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-266599
DOI:	10.1002/ijc.30123
Journal or Publication Title:	Int. J. Cancer
Volume:	139
Number:	4
Page Range:	S. 749 - 754
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVE-SURVEILLANCE; SURVIVAL; BIAS Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26659