Universität zu Köln

Zugor, Vahudin, Poth, Sandor, Kuehn, Reinhard, Bernat, Marija Maja, Porres, Daniel and Labanaris, Apostolos P. (2016). Is an Extended Prostate Biopsy Scheme Associated with an Improvement in the Accuracy Between the Biopsy Gleason Score and Radical Prostatectomy Pathology? A Multivariate Analysis. Anticancer Res., 36 (8). S. 4285 - 4289. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Aim: To examine whether an extended prostate biopsy (PB) scheme is associated with an improvement in the accuracy between the PB Gleason score (GS) and radical prostatectomy (RP) pathology and to identify probable preoperative variables that stratified patients likely to harbor significant upgrading (SU). Patients and Methods: A retrospective review of 538 patients' records diagnosed with prostate cancer (PCa) who underwent RP and exhibited a SU, at two tertiary medical centers, was conducted. The patients were divided into 3 groups: 194 who underwent a 6-core PB (36%), 156 who underwent a 12-core PB (28.9%) and 188 (34.9%) who underwent an 18-core PB. A multivariate analysis was conducted, including prostate-specific antigen (PSA) level, clinical stage, prostate size and duration from PB to RP. Results: The 6-core group exhibited a 42.7% SU, the 12-core group exhibited a 38.8% SU and the 18-core group exhibited a 14.1% SU. There was a highly significant lower rate of SU in the 18-core than that in the 6-core (p<0.001) and 12-core PB group (p<0.001) but no significant difference in the rate of SU was noted between the 6- and 12-core group (p=0.913). According to the multivariate analysis, only a prostate size of >35 g significantly elevated the probability of SU in the 6-core (p<0.025) and 12-core PB groups (p<0.025), respectively. Conclusion: An extended PB scheme is associated with a significant improvement in the accuracy between the PB GS and RP pathology. Prostate size >35 g in patients who undergo a 6- or 12-core PB is the only preoperative variable that stratifies patients likely to harbor SU.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zugor, Vahudin UNSPECIFIED UNSPECIFIED UNSPECIFIED Poth, Sandor UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuehn, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernat, Marija Maja UNSPECIFIED UNSPECIFIED UNSPECIFIED Porres, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Labanaris, Apostolos P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-267463
Journal or Publication Title:	Anticancer Res.
Volume:	36
Number:	8
Page Range:	S. 4285 - 4289
Date:	2016
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER; ULTRASOUND; MRI Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26746