Universität zu Köln

Jarczok, Tomasz A., Fritsch, Merve, Kroeger, Anne, Schneider, Anna Lisa, Althen, Heike, Siniatchkin, Michael, Freitag, Christine M. and Bender, Stephan (2016). Maturation of interhemispheric signal propagation in autism spectrum disorder and typically developing controls: a TMS-EEG study. J. Neural Transm., 123 (8). S. 925 - 936. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Brain maturation from childhood to adulthood is associated with changes in structural and functional connectivity between remote brain regions. Altered connectivity plays an important role in the pathology of autism spectrum disorder (ASD), a severe neurodevelopmental disorder. ASD is associated with abnormal brain development and structurally altered interhemispheric connections. Cortico-cortical connectivity can be studied by a combination of transcranial magnetic stimulation (TMS) with concurrent EEG (TMS-EEG). TMS-evoked Interhemispheric Signal Propagation (ISP) is a correlate of interhemispheric connectivity related to the microstructure of the corpus callosum (CC). We used TMS-EEG to measure ISP in 22 ASD subjects (10-21 years) and 22 typically developing control subjects (9-19 years). We expected (1) maturational changes of ISP from childhood to young adulthood and also (2) reduced interhemispheric signal transfer in ASD. ISP was positively correlated with age in both ASD and typically developing control subjects. No difference in ISP between ASD and typically developing controls was found. Our findings demonstrate maturation of effective interhemispheric connectivity during adolescence. As ISP is related to the microstructure of the CC, the developmental change of ISP likely reflects maturation of the CC during the second life decade. The results support ISP as a valid parameter reflecting functional interhemispheric connectivity. Our results do not support a global deficit of interhemispheric connectivity in ASD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jarczok, Tomasz A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritsch, Merve UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Anna Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Althen, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Siniatchkin, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Freitag, Christine M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-268380
DOI:	10.1007/s00702-016-1550-5
Journal or Publication Title:	J. Neural Transm.
Volume:	123
Number:	8
Page Range:	S. 925 - 936
Date:	2016
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; HIGH-FUNCTIONING AUTISM; WHITE-MATTER DEVELOPMENT; PRIMARY MOTOR CORTEX; CORPUS-CALLOSUM; CORTICAL INHIBITION; BRAIN-DEVELOPMENT; LATE ADOLESCENCE; CHILDREN; CONNECTIVITY Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26838