Universität zu Köln

Kumar, Atul, Paeger, Lars ORCID: 0000-0001-8716-3483, Kosmas, Kosmas, Kloppenburg, Peter, Noegel, Angelika A. and Peche, Vivek S. (2016). Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2. Front. Cell. Neurosci., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5102

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Abstract

Actin remodeling is crucial for dendritic spine development, morphology and density. CAP2 is a regulator of actin dynamics through sequestering G-actin and severing F-actin. In a mouse model, ablation of CAP2 leads to cardiovascular defects and delayed wound healing. This report investigates the role of CAP2 in the brain using Cap2(gt)/(gt) mice. Dendritic complexity, the number and morphology of dendritic spines were altered in Cap2(gt)/(gt) with increased number of excitatory synapses. This was accompanied by increased F-actin content and F-actin accumulation in cultured Cap2(gt)/(gt) neurons. Moreover, reduced surface GluA1 was observed in mutant neurons under basal condition and after induction of chemical LTP. Additionally, we show an interaction between CAP2 and n-cofilin, presumably mediated through the C-terminal domain of CAP2 and dependent on cofilin Ser3 phosphorylation. In vivo, the consequences of this interaction were altered phosphorylated cofilin levels and formation of cofilin aggregates in the neurons. Thus, our studies identify a novel role of CAP2 in neuronal development and neuronal actin dynamics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kumar, Atul UNSPECIFIED UNSPECIFIED UNSPECIFIED Paeger, Lars UNSPECIFIED orcid.org/0000-0001-8716-3483 UNSPECIFIED Kosmas, Kosmas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloppenburg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Noegel, Angelika A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peche, Vivek S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-269578
DOI:	10.3389/fncel.2016.00180
Journal or Publication Title:	Front. Cell. Neurosci.
Volume:	10
Date:	2016
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYCLASE-ASSOCIATED PROTEIN-2; AMPA RECEPTOR TRAFFICKING; LONG-TERM POTENTIATION; EXCITATORY SYNAPSES; SYNAPTIC PLASTICITY; BRAIN-SLICES; COFILIN; CYTOSKELETON; MORPHOLOGY; POLYMERIZATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26957