Universität zu Köln

Jahchan, Nadine S., Lim, Jing Shan, Bola, Becky ORCID: 0000-0002-8985-9713, Morris, Karen, Seitz, Garrett, Tran, Kim Q., Xu, Lei, Trapani, Francesca, Morrow, Christopher J., Cristea, Sandra, Coles, Garry L., Yang, Dian, Vaka, Dedeepya, Kareta, Michael S., George, Julie, Mazur, Pawel K., Nguyen, Thuyen, Anderson, Wade C., Dylla, Scott J., Blackhall, Fiona ORCID: 0000-0001-8716-3395, Peifer, Martin ORCID: 0000-0002-5243-5503, Dive, Caroline ORCID: 0000-0002-1726-8850 and Sage, Julien (2016). Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer. Cell Reports, 16 (3). S. 644 - 657. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-term tumor-propagating cells (TPCs) in a mouse model of SCLC. This population, marked by high levels of EpCAM and CD24, is also prevalent in human primary SCLC tumors. Murine SCLC TPCs are numerous and highly proliferative but not intrinsically chemoresistant, indicating that not all clinical features of SCLC are linked to TPCs. SCLC TPCs possess a distinct transcriptional profile compared to non-TPCs, including elevated MYC activity. Genetic and pharmacological inhibition of MYC in SCLC cells to non-TPC levels inhibits long-term propagation but not short-term growth. These studies identify a highly tumorigenic population of SCLC cells in mouse models, cell lines, and patient tumors and a means to target them in this most fatal form of lung cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jahchan, Nadine S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lim, Jing Shan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bola, Becky UNSPECIFIED orcid.org/0000-0002-8985-9713 UNSPECIFIED Morris, Karen UNSPECIFIED UNSPECIFIED UNSPECIFIED Seitz, Garrett UNSPECIFIED UNSPECIFIED UNSPECIFIED Tran, Kim Q. UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Lei UNSPECIFIED UNSPECIFIED UNSPECIFIED Trapani, Francesca UNSPECIFIED UNSPECIFIED UNSPECIFIED Morrow, Christopher J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cristea, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Coles, Garry L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Dian UNSPECIFIED UNSPECIFIED UNSPECIFIED Vaka, Dedeepya UNSPECIFIED UNSPECIFIED UNSPECIFIED Kareta, Michael S. UNSPECIFIED UNSPECIFIED UNSPECIFIED George, Julie UNSPECIFIED UNSPECIFIED UNSPECIFIED Mazur, Pawel K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nguyen, Thuyen UNSPECIFIED UNSPECIFIED UNSPECIFIED Anderson, Wade C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dylla, Scott J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blackhall, Fiona UNSPECIFIED orcid.org/0000-0001-8716-3395 UNSPECIFIED Peifer, Martin UNSPECIFIED orcid.org/0000-0002-5243-5503 UNSPECIFIED Dive, Caroline UNSPECIFIED orcid.org/0000-0002-1726-8850 UNSPECIFIED Sage, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-269782
DOI:	10.1016/j.celrep.2016.06.021
Journal or Publication Title:	Cell Reports
Volume:	16
Number:	3
Page Range:	S. 644 - 657
Date:	2016
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BET BROMODOMAIN INHIBITION; STEM-CELL; MOUSE MODEL; GENE-EXPRESSION; C-KIT; HETEROGENEITY; ASCL1; SCLC; INACTIVATION; SENSITIVITY Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26978