Universität zu Köln

Biscaldi, M., Bednorz, N., Weissbrodt, K., Saville, C. W. N., Feige, B., Bender, S. and Klein, C. (2016). Cognitive endophenotypes of attention deficit/hyperactivity disorder and intra-subject variability in patients with autism spectrum disorder. Biol. Psychol., 118. S. 25 - 35. AMSTERDAM: ELSEVIER. ISSN 1873-6246

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Abstract

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have previously been studied mainly in isolation from each other. However the two conditions may be aetiologically related and thus show overlap in aetiologically relevant functions. In order to address this question of potential aetiological overlap between ADHD and ASD, the present study set out to investigate putative endophenotypes of ADHD in N = 33 typically developing (TD) children and N = 28 patients with ASD that were (ASD+) or were not (ASD-) co-morbid for ADHD. With regard to both the cognitive endophenotype candidates (working memory, inhibition, temporal processing) and intra-subject variability (ISV) the pattern of abnormalities was inconsistent. Furthermore, the overall profile of ASD-TD differences was extremely similar to the pattern of differences between the ASD+ and ASD-sub-groups, suggesting that any abnormalities found were due to the comorbid ASD subgroup. This held in particular for ISV, which did not show in patients with ASD the task-general increase that is common in ADHD samples. Altogether, the present results do not support the hypothesis of aetiological overlap between ASD and ADHD. (C) 2016 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Biscaldi, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bednorz, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weissbrodt, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saville, C. W. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feige, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270299
DOI:	10.1016/j.biopsycho.2016.04.064
Journal or Publication Title:	Biol. Psychol.
Volume:	118
Page Range:	S. 25 - 35
Date:	2016
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-6246
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REACTION-TIME VARIABILITY; DEFICIT HYPERACTIVITY DISORDER; HIGH-FUNCTIONING AUTISM; WORKING-MEMORY; BEHAVIORAL-INHIBITION; INTRAINDIVIDUAL VARIABILITY; GENETIC INFLUENCES; ADHD; CHILDREN; REPRODUCTION Multiple languages Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27029