Universität zu Köln

Banaschewski, T., Gerlach, M., Becker, K., Holtmann, M., Doepfner, M. and Romanos, M. (2016). Trust, but verify. The errors and misinterpretations in the Cochrane analysis by O. J. Storebo and colleagues on the efficacy and safety of methylphenidate for the treatment of children and adolescents with ADHD. Z. Kinder-und Jugendpsy. Psychother., 44 (4). S. 307 - 315. BERN 9: VERLAG HANS HUBER. ISSN 1664-2880

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Abstract

Objective: A recent Cochrane review published by O. J. Storebo and colleagues (2015) raised substantial doubts about the benefit from stimulant medication with methylphenidate in the treatment of childhood ADHD due to the overall poor quality of studies. The systematic review thus contradicts all previous reviews and meta-analyses. Method: We here detail various examples of errors, inconsistencies, and misinterpretations in the review which led to false results and inadequate conclusions. Results: We demonstrate that the study selection is flawed and undertaken without sufficient scientific justification resulting in an underestimation of effect sizes, which, furthermore, are inadmissibly clinically interpreted. The methodology of the assessment of bias and quality is not objective and cannot be substantiated by the data. Conclusions: Cochrane reviews lay claim to a high scientific quality and substantial relevance for evidence-based clinical decisions. The systematic review by Storebo and colleagues (2015) illustrates that, despite adhering to strict standards and high-quality protocols, even Cochrane works should be critically read and verified, sometimes with surprising results.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Banaschewski, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerlach, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmann, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doepfner, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Romanos, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270550
DOI:	10.1024/1422-4917/a000433
Journal or Publication Title:	Z. Kinder-und Jugendpsy. Psychother.
Volume:	44
Number:	4
Page Range:	S. 307 - 315
Date:	2016
Publisher:	VERLAG HANS HUBER
Place of Publication:	BERN 9
ISSN:	1664-2880
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; DOUBLE-BLIND; CONTROLLED-TRIAL; PLACEBO; METAANALYSIS; DEXMETHYLPHENIDATE; INTERVENTIONS; MEDICATIONS; ATOMOXETINE Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27055