Universität zu Köln

Pfister, David, Porres, Daniel, Heidenreich, Axel, Heidegger, Isabel, Knuechel, Ruth, Steib, Florian, Behrendt, Florian F. and Verburg, Frederik A. (2016). Detection of recurrent prostate cancer lesions before salvage lymphadenectomy is more accurate with Ga-68-PSMA-HBED-CC than with F-18-Fluoroethylcholine PET/CT. Eur. J. Nucl. Med. Mol. Imaging, 43 (8). S. 1410 - 1418. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Aim [Ga-68]PSMA-HBED-CC (Ga-68-PSMA) is a novel and promising tracer for highly sensitive combined integrated positron emission tomography and X-ray computed tomography (PET/CT) diagnosis of recurrent prostate cancer (PCA). Our aim was to assess the sensitivity, specificity, positive and negative predictive value (PPV/NPV), and accuracy per lesion, as well as the positive predictive value per patient of Ga-68-PSMA PET/CT using post-lymphadenectomy histology as a standard, and to compare these values to those obtained in a patient collective scanned using F-18-Fluoroethylcholine ((FEC)-F-18) PET/CT. Methods Thirty eight patients had (FEC)-F-18 and 28 patients had Ga-68-PSMA. We performed a pelvic and/or retroperitoneal lymphadenectomy, if necessary supplemented by resection of locally recurrent lesions in accordance with imaging results. Results In 30/38 (FEC)-F-18 and 23/28 Ga-68-PSMA patients a parts per thousand yen1 focus of PCA was identified in postsurgical histology, leading to a per-patient PPV of 78.9 % for (FEC)-F-18 and 82.1 % for Ga-68-PSMA. In (FEC)-F-18 and Ga-68-PSMA patients, a total of 378 and 308 lymph nodes and local lesions were removed, respectively. For (FEC)-F-18 and (68)for Ga-PSMA, the respective sensitivity (95 % confidence interval) was 71.2 % (64.5-79.6 %) and 86.9 % (75.8-94.2 %), specificity was 86.9 % (82.3-90.6 % ) and 93.1 % (89.2-95.9 %), PPV was 67.3 % (57.7-75.9 %) and 75.7 % (64.0-98.5 %), NPV was 88.8 % (84.4-92.3 %) and 96.6 % (93.5-98.5 %), and accuracy was 82.5 % (78.3-86.8 %) and 91.9 % (88.7 %-95.1 %). Conclusion In the present series Ga-PSMA PET/CT shows a better performance than FEC PET/CT with a significantly higher NPV and accuracy for the detection of locoregional recurrent and/or metastatic lesions prior to salvage lymphadenectomy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfister, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Porres, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidegger, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Knuechel, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Steib, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrendt, Florian F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verburg, Frederik A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-271225
DOI:	10.1007/s00259-016-3366-9
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	43
Number:	8
Page Range:	S. 1410 - 1418
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GA-68-LABELED PSMA LIGAND; LYMPH-NODE DISSECTION; BIOCHEMICAL RECURRENCE; F-18-CHOLINE PET/CT; DIAGNOSIS; METASTASIS; THERAPY; FAILURE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27122