Universität zu Köln

Zimmer, P., Oberste, M., Bloch, W., Schenk, A., Joisten, N., Hartig, P., Wolf, F., Baumann, F. T., Garthe, A., Hallek, M. and Elter, T. (2016). Impact of aerobic exercise training during chemotherapy on cancer related cognitive impairments in patients suffering from acute myeloid leukemia or myelodysplastic syndrome - Study protocol of a randomized placebo-controlled trial. Contemp. Clin. Trials, 49. S. 1 - 6. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1559-2030

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Abstract

Cancer related cognitive impairments (CRCI) are frequently reported by patients prior to, during and after medical treatment. Although this cognitive decline severely affects patients' quality of life, little is known about effective treatments. Exercise programs represent a promising supportive strategy in this field. However, evidence is sparse and existing studies display methodological limitations. In the planned study, 83 men and women newly diagnosed with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) will be randomized into one of three treatment groups. During 4 weeks of induction chemotherapy with Anthracycline and Cytarabin patients allocated to exercise group will cycle 3 x/week for 30 min at moderate to vigorous intensity on an ergometer. Patients allocated to placebo group will receive a supervised myofascial release training (3x/week, approx. 30 min) and patients at control group will get usual care. As primary endpoints a cognitive test battery will be conducted measuring performances depending on verbal/spatial memory and executive functioning. Secondary endpoints will be self-perceived cognitive functioning, as well as neurotrophic and inflammatory serum markers. All assessments will be conducted immediately after hospitalization and before chemotherapy is commenced, immediately before discharge of hospital after 45 weeks as well as before continuing medical treatment 3-4 weeks after discharge. This will be the first study investigating the impact of an aerobic exercise training on CRCI in AML/MDS patients. We hope that the study design and the state-of-the-art assessments will help to increase knowledge about CRCI in general and exercise as potential treatment option in this under investigated population. (C) 2016 Elsevier Inc All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zimmer, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberste, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Joisten, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartig, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, F. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garthe, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elter, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-271361
DOI:	10.1016/j.cct.2016.05.007
Journal or Publication Title:	Contemp. Clin. Trials
Volume:	49
Page Range:	S. 1 - 6
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1559-2030
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIPPOCAMPAL NEUROGENESIS; PHYSICAL-ACTIVITY; BREAST-CANCER; MANAGEMENT; IRRADIATION; INSTRUMENT; RISK Multiple languages Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27136