Universität zu Köln

Kleine, Justus F., Boeckh-Behrens, Tobias, Prothmann, Sascha ORCID: 0000-0002-3964-3885, Zimmer, Claus and Liebig, Thomas ORCID: 0000-0001-5640-7780 (2016). Discrepancy between early neurological course and mid-term outcome in older stroke patients after mechanical thrombectomy. J. NeuroInterventional Surg., 8 (7). LONDON: BMJ PUBLISHING GROUP. ISSN 1759-8486

Full text not available from this repository.

Abstract

Background Stroke in aged patients has a relatively poor prognosis, even after recanalizing therapy. Potential reasons include mechanisms that relate directly to the extent of brain tissue damage, but also age-dependent factors which are not, or only indirectly, stroke-related, such as pre-existing functional deficits, comorbidities, and post-stroke complications (eg, infections). Objective To compare early neurological course with subsequent functional outcome in older (>= 80 years) and younger stroke patients in order to estimate the relative impact of these factors. Specifically, to examine if the strong age-dependency of modified Rankin Scale (mRS) outcome scores in stroke patients after mechanical thrombectomy is paralleled by a similar age dependency of early postinterventional National Institute of Health Stroke Scale (NIHSS) scores-a more specific measure of stroke-induced brain damage. Methods We evaluated technical results, pre-and postinterventional NIHSS scores, mid-term mRS scores and early and overall mortality and their relation to age in 125 patients, 40 of them >= 80 years, with acute middle cerebral artery occlusion, treated by mechanical thrombectomy. Results Technical success, pre-and postinterventional NIHSS scores and early mortality were age-independent. Early neurological improvement depended on successful recanalization, but not on age. Nevertheless, good mRS outcome (mRS 0-2) was much rarer, and overall mortality almost threefold higher in aged patients. Conclusions Older patients exhibit a similar early neurological course and responsiveness to mechanical thrombectomy as younger patients, but this is not reflected in mid-term functional outcome scores. This indicates that post-stroke complications and other factors that are not, or only indirectly, related to the brain tissue damage induced by the incident stroke have a dominant role in their poor prognosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kleine, Justus F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boeckh-Behrens, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Prothmann, Sascha UNSPECIFIED orcid.org/0000-0002-3964-3885 UNSPECIFIED Zimmer, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebig, Thomas UNSPECIFIED orcid.org/0000-0001-5640-7780 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-271601
DOI:	10.1136/neurintsurg-2015-011702
Journal or Publication Title:	J. NeuroInterventional Surg.
Volume:	8
Number:	7
Date:	2016
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1759-8486
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE ISCHEMIC-STROKE; ENDOVASCULAR THERAPY; AGE DEPENDENCY; SCALE; RECANALIZATION; THROMBOLYSIS; BURDEN; TRIALS; COHORT; BRAIN Multiple languages Neuroimaging; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27160