Universität zu Köln

Heimes, B., Schick, T., Brinkmann, C. K., Wiedon, A., Haegele, B., Kirchhof, B., Holz, F. G., Pauleikhoff, D., Ziemssen, F., Liakopoulos, S., Spital, G. and Schmitz-Valckenberg, S. (2016). Design of the ORCA module in the OCEAN study. Evaluation of SD-OCT results in daily routine practice. Ophthalmologe, 113 (7). S. 570 - 581. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423

Full text not available from this repository.

Abstract

The prevalence of blindness as defined by law could be reduced by the introduction of anti-vascular endothelial growth factor (VEGF) therapy. Because the treatment is governed by patient needs, mostly using morphological criteria, imaging diagnostics are of particular importance. The non-interventional OCEAN study investigates the treatment with ranibizumab in the clinical routine practice. In a subgroup of patients the interpretation of spectral domain optical coherence tomography (SD-OCT) scans by the treating physicians will be analyzed (ORCA module). Over a period of 24 months data from patients with exudative age-related macular degeneration (AMD), macular edema due to retinal vein occlusion or diabetes mellitus, who are receiving intravitreal injections of ranibizumab, will be assessed. Information on examinations, visual acuity, treatment and recordings from imaging techniques will be documented using a questionnaire. The SD-OCT scans, fluorescence angiography and fundus photography will be independently analyzed by the ophthalmologist of the study center and by three reading centers (CIRCL Cologne, GRADE Bonn and M3 Munster). Automated measurements of retinal thickness by the manufacturers' software will be checked and if necessary manually corrected. A qualitative interpretation in terms of morphological criteria for (further) treatment will be performed. A thorough assessment of SD-OCT images during anti-VEGF therapy provides the basis for the best possible needs-oriented treatment regimen. The control of the quality of data from daily routine practice may indicate possible weaknesses allowing explicit training and therefore optimization of patient treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heimes, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkmann, C. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiedon, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haegele, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holz, F. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauleikhoff, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziemssen, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spital, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz-Valckenberg, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-271709
DOI:	10.1007/s00347-016-0224-x
Journal or Publication Title:	Ophthalmologe
Volume:	113
Number:	7
Page Range:	S. 570 - 581
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR THERAPY; MACULAR DEGENERATION; VISUAL IMPAIRMENT; BLINDNESS Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27170