Marshall-Goebel, Karina ORCID: 0000-0002-5240-7625, Ambarki, Khalid, Eklund, Anders ORCID: 0000-0002-2031-722X, Malm, Jan ORCID: 0000-0001-6451-1940, Mulder, Edwin, Gerlach, Darius ORCID: 0000-0001-7044-6065, Bershad, Eric ORCID: 0000-0003-4091-2031 and Rittweger, Joern (2016). Effects of short-term exposure to head-down tilt on cerebral hemodynamics: a prospective evaluation of a spaceflight analog using phase-contrast MRI. J. Appl. Physiol., 120 (12). S. 1466 - 1474. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1601

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Abstract

Alterations in cerebral hemodynamics in microgravity are hypothesized to occur during spaceflight and could be linked to the Visual Impairment and Intracranial Pressure syndrome. Head-down tilt (HDT) is frequently used as a ground-based analog to simulate cephalad fluid shifts in microgravity; however, its effects on cerebral hemodynamics have not been well studied with MRI techniques. Here, we evaluate the effects of 1) various HDT angles on cerebral arterial and venous hemodynamics; and 2) exposure to 1% CO2 during an intermediate HDT angle (-12 degrees) as an additional space-related environmental factor. Blood flow, cross-sectional area (CSA), and blood flow velocity were measured with phase-contrast MRI in the internal jugular veins, as well as the vertebral and internal carotid arteries. Nine healthy male subjects were measured at baseline (supine, 0 degrees) and after 4.5 h of HDT at -6 degrees, -12 degrees (with and without 1% CO2), and -18 degrees. We found a decrease in total arterial blood flow from baseline during all angles of HDT. On the venous side, CSA increased with HDT, and outflow decreased during -12 degrees HDT (P = 0.039). Moreover, the addition of 1% CO2 to -12 degrees HDT caused an increase in total arterial blood flow (P = 0.016) and jugular venous outflow (P = 0.001) compared with -12 degrees HDT with ambient atmosphere. Overall, the results indicate decreased cerebral blood flow during HDT, which may have implications for microgravity-induced cerebral hemodynamic changes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Marshall-Goebel, KarinaUNSPECIFIEDorcid.org/0000-0002-5240-7625UNSPECIFIED
Ambarki, KhalidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eklund, AndersUNSPECIFIEDorcid.org/0000-0002-2031-722XUNSPECIFIED
Malm, JanUNSPECIFIEDorcid.org/0000-0001-6451-1940UNSPECIFIED
Mulder, EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, DariusUNSPECIFIEDorcid.org/0000-0001-7044-6065UNSPECIFIED
Bershad, EricUNSPECIFIEDorcid.org/0000-0003-4091-2031UNSPECIFIED
Rittweger, JoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-272206
DOI: 10.1152/japplphysiol.00841.2015
Journal or Publication Title: J. Appl. Physiol.
Volume: 120
Number: 12
Page Range: S. 1466 - 1474
Date: 2016
Publisher: AMER PHYSIOLOGICAL SOC
Place of Publication: BETHESDA
ISSN: 1522-1601
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LONG-DURATION SPACEFLIGHT; BLOOD-FLOW VELOCITY; CO2 REACTIVITY; CARBON-DIOXIDE; THIGH CUFFS; SPACE; PRESSURE; ADAPTATION; ARTERIAL; AUTOREGULATIONMultiple languages
Physiology; Sport SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27220

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