Universität zu Köln

Juvin, Laurent ORCID: 0000-0001-8847-1891, Gratsch, Swantje, Trillaud-Doppia, Emilie, Gariepy, Jean-Francois, Büschges, Ansgar ORCID: 0000-0003-2123-1900 and Dubuc, Rejean (2016). A Specific Population of Reticulospinal Neurons Controls the Termination of Locomotion. Cell Reports, 15 (11). 2377 - 2387. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Full text not available from this repository.

Abstract

Locomotion requires the proper sequencing of neural activity to start, maintain, and stop it. Recently, brainstem neurons were shown to specifically stop locomotion in mammals. However, the cellular properties of these neurons and their activity during locomotion are still unknown. Here, we took advantage of the lamprey model to characterize the activity of a cell population that we now show to be involved in stopping locomotion. We find that these neurons display a burst of spikes that coincides with the end of swimming activity. Their pharmacological activation ends ongoing swimming, whereas the inactivation of these neurons dramatically impairs the rapid termination of swimming. These neurons are henceforth referred to as stop cells, because they play a crucial role in the termination of locomotion. Our findings contribute to the fundamental understanding of motor control and provide important details about the cellular mechanisms involved in locomotor termination.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Juvin, Laurent UNSPECIFIED orcid.org/0000-0001-8847-1891 UNSPECIFIED Gratsch, Swantje UNSPECIFIED UNSPECIFIED UNSPECIFIED Trillaud-Doppia, Emilie UNSPECIFIED UNSPECIFIED UNSPECIFIED Gariepy, Jean-Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Büschges, Ansgar UNSPECIFIED orcid.org/0000-0003-2123-1900 UNSPECIFIED Dubuc, Rejean UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-272261
DOI:	10.1016/j.celrep.2016.05.029
Journal or Publication Title:	Cell Reports
Volume:	15
Number:	11
Page Range:	2377 - 2387
Date:	2016
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Zoologisches Institut
Subjects:	Life sciences
Uncontrolled Keywords:	Keywords Language HATCHLING FROG TADPOLES; BRAIN-STEM; READINESS DISCHARGE; INHIBITION; ACTIVATION; INITIATION; COMMAND; REGION; TRANSFORMATION; CIRCUITS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27226