Universität zu Köln

Aaltonen, Mari J., Friedman, Jonathan R., Osman, Christof, Salin, Benedicte, Di Rago, Jean-Paul, Nunnari, Jodi, Langer, Thomas ORCID: 0000-0003-1250-1462 and Tatsuta, Takashi (2016). MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. J. Cell Biol., 213 (5). S. 525 - 535. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-8140

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Abstract

Mitochondria exert critical functions in cellular lipid metabolism and promote the synthesis of major constituents of cellular membranes, such as phosphatidylethanolamine (PE) and phosphatidylcholine. Here, we demonstrate that the phosphatidylserine decarboxylase Psd 1, located in the inner mitochondrial membrane, promotes mitochondrial PE synthesis via two pathways. First, Ups2-Mdm35 complexes (SLMO2-TRIAP1 in humans) serve as phosphatidylserine (135)-specific lipid transfer proteins in the mitochondrial intermembrane space, allowing formation of PE by Psd1 in the inner membrane. Second, Psd1 decarboxylates PS in the outer membrane in trans, independently of PS transfer by Ups2-Mdm35. This latter pathway requires close apposition between both mitochondrial membranes and the mitochondrial contact site and cristae organizing system (MICOS). In MICOS-deficient cells, limiting PS transfer by Ups2-Mdm35 and reducing mitochondria! PE accumulation preserves mitochondrial respiration and cristae formation. These results link mitochondria! PE metabolism to MICOS, combining functions in protein and lipid homeostasis to preserve mitochondrial structure and function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Aaltonen, Mari J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedman, Jonathan R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Osman, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Salin, Benedicte UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Rago, Jean-Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Nunnari, Jodi UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED Tatsuta, Takashi UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-272449
DOI:	10.1083/jcb.201602007
Journal or Publication Title:	J. Cell Biol.
Volume:	213
Number:	5
Page Range:	S. 525 - 535
Date:	2016
Publisher:	ROCKEFELLER UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1540-8140
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONTACT SITES; INTRAMITOCHONDRIAL TRANSPORT; BIOSYNTHETIC PATHWAYS; PHOSPHATIDIC-ACID; PHOSPHATIDYLETHANOLAMINE; CARDIOLIPIN; YEAST; PROTEINS; CRISTAE; UPS1-MDM35 Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27244