Abbas, Mahmoud, Steffens, Sandra, Bellut, Maria, Becker, Jan U., Grosshennig, Anika, Eggers, Hendrik, Wegener, Gerd, Kuczyk, Markus A., Kreipe, Hans H., Gruenwald, Viktor, Schrader, Andres J. and Ivanyi, Philipp ORCID: 0000-0002-2862-7302 (2016). Do programmed death 1 (PD-1) and its ligand (PD-L1) play a role in patients with non-clear cell renal cell carcinoma? Med. Oncol., 33 (6). TOTOWA: HUMANA PRESS INC. ISSN 1559-131X

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Abstract

Clinical trials targeting programmed death 1 (PD-1) and its ligand PD-L1 (PD-L1) for metastatic renal cell cancer (RCC) are ongoing. The aim of this study is to validate their roles as prognostic markers in non-clear cell (non-cc) RCC. Sixty-four non-cc RCC tissue specimens were collected from patients undergoing renal tumor surgery. Expressions of biomarkers were assessed using immunohistochemistry and compared with clinical characteristics. Survival analyses were performed with a median follow-up of 77.5 (range: 0-176) months. No significant correlations were found for PD-1(+) tumor-infiltrating mononuclear cells (TIMC) or PD-L1(+) expression and clinical attributes in patients with non-cc RCC. Kaplan-Meier analysis revealed no differences in 5- and 10-year cancer-specific survival (CSS) for PD-1-TIMC compared to PD-1(+) TIMC (71.4 and 63 % versus 72.2 and 61.9 %; p = 0.88). Intratumoral expression of PD-L1 did not appear to influence the 5-and 10-year CSS significantly, even though a trend was identified (68 and 53.6 % versus 80.1 and 75.7 %; p = 0.08). In multivariate analysis, neither PD-1(+) TIMC nor intratumoral PD-L1(+) expression proved to be independent predictors of CSS (p = 0.99 and p = 0.68, respectively). Our study demonstrates that PD-1(+) TIMC and intratumoral PD-L1(+) expression did not significantly impact tumor aggressiveness or clinical outcome in non-ccRCC specimens. Due to rare incidence of non-cc RCC in particular according to PD-L1 expression, further analyzes are warranted.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Abbas, MahmoudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steffens, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bellut, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, Jan U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grosshennig, AnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eggers, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wegener, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuczyk, Markus A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreipe, Hans H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruenwald, ViktorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrader, Andres J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivanyi, PhilippUNSPECIFIEDorcid.org/0000-0002-2862-7302UNSPECIFIED
URN: urn:nbn:de:hbz:38-273668
DOI: 10.1007/s12032-016-0770-8
Journal or Publication Title: Med. Oncol.
Volume: 33
Number: 6
Date: 2016
Publisher: HUMANA PRESS INC
Place of Publication: TOTOWA
ISSN: 1559-131X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
T-CELLS; B7-H1; MECHANISM; SURVIVAL; MEMBERMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27366

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