Universität zu Köln

Soresi, Simona, Zeriouh, Mohamed, Sabashnikov, Anton ORCID: 0000-0002-6289-1035, Sarang, Zubair, Mohite, Prashant N., Patil, Nikhil P., Mansur, Ashham ORCID: 0000-0002-0322-2480, Weymann, Alexander, Wippermann, Jens, Wahlers, Thorsten, Reed, Anna, Carby, Martin, Simon, Andre R. and Popov, Aron-Frederik ORCID: 0000-0003-4226-3004 (2016). Extended Recipient Criteria in Lung Transplantation: Impact of Pleural Abnormalities on Primary Graft Dysfunction. Ann. Thorac. Surg., 101 (6). S. 2112 - 2120. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1552-6259

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Abstract

Background. Because of improved surgical expertise and intraoperative management, pleural disease (PD+) represents a relatively minor contraindication to lung transplantation (LTx). The presence of pleural abnormalities from previous procedures or pleural involvement from fungal or bacterial disease is not considered a limiting factor for LTx. However there are no studies available to assess the impact of pleural diseases on short-and midterm outcomes after LTx. Methods. We retrospectively reviewed 163 consecutive patients who underwent LTx between 2010 and 2013. Patients were divided according to the presence of pleural abnormalities before the operation (PD+ versus PD-). The primary end point of the study was primary graft dysfunction (PGD; grade 3) and overall survival. To avoid possible selection bias and to heck the robustness of the results, a propensity score-matching analysis (1:3) was performed. Results. A total of 26 patients (16%) had pleural abnormalities before transplantation. Intra-and postoperative variables were comparable. PD+ was associated with a significantly higher incidence of PGD at 0 and 48 hours postoperatively (p = 0.037 and p = 0.032, respectively). Moreover, PD+ was associated with significantly worse survival at 3 months (p = 0.021). Although there was a trend toward worse early overall survival in the Kaplan-Meier estimate (Breslow p = 0.050), midterm survival was comparable (log-rank p = 0.240). Conclusions. LTx in patients with preoperative pleural abnormalities is feasible. Identifying higher-risk recipients with pleural abnormalities might have important clinical relevance because of a higher incidence of PGD and worse early survival, even though midterm survival is comparable. (C) 2016 by The Society of Thoracic Surgeons

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Soresi, Simona UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeriouh, Mohamed UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED orcid.org/0000-0002-6289-1035 UNSPECIFIED Sarang, Zubair UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohite, Prashant N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patil, Nikhil P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mansur, Ashham UNSPECIFIED orcid.org/0000-0002-0322-2480 UNSPECIFIED Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Wippermann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Reed, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Carby, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Andre R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Popov, Aron-Frederik UNSPECIFIED orcid.org/0000-0003-4226-3004 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273953
DOI:	10.1016/j.athoracsur.2015.11.068
Journal or Publication Title:	Ann. Thorac. Surg.
Volume:	101
Number:	6
Page Range:	S. 2112 - 2120
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1552-6259
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACORPOREAL MEMBRANE-OXYGENATION; BRONCHIOLITIS-OBLITERANS-SYNDROME; CYSTIC-FIBROSIS PATIENTS; ISHLT WORKING GROUP; RISK-FACTORS; INTERNATIONAL-SOCIETY; ADULT LUNG; SURVIVAL; REGISTRY; FAILURE Multiple languages Cardiac & Cardiovascular Systems; Respiratory System; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27395