Madorsky-Feldman, Dana, Sklair-Levy, Miri, Perri, Tamar ORCID: 0000-0002-4042-6554, Laitman, Yael, Paluch-Shimon, Shani, Schmutzler, Rita, Rhiem, Kerstin, Lester, Jenny, Karlan, Beth Y., Singer, Christian F., Van Maerken, Tom, Claes, Kathleen ORCID: 0000-0003-0841-7372, Brunet, Joan ORCID: 0000-0003-1945-3512, Izquierdo, Angel, Teule, Alex ORCID: 0000-0003-0028-7200, Lee, Jong Won, Kim, Sung-Won, Arun, Banu, Jakubowska, Anna ORCID: 0000-0002-5650-0501, Lubinski, Jan ORCID: 0000-0003-2931-3003, Tucker, Katherine, Poplawski, Nicola K., Varesco, Liliana ORCID: 0000-0003-4871-6668, Bonelli, Luigina Ada ORCID: 0000-0002-9034-9630, Buys, Saundra S., Mitchell, Gillian, Tischkowitz, Marc ORCID: 0000-0002-7880-0628, Gerdes, Anne-Marie ORCID: 0000-0002-0328-3320, Seynaeve, Caroline, Robson, Mark, Kwong, Ava ORCID: 0000-0002-6968-9489, Tung, Nadine, Tessa, Nalven, Domchek, Susan M., Godwin, Andrew K., Rantala, Johanna, Arver, Brita and Friedman, Eitan (2016). An international survey of surveillance schemes for unaffected BRCA1 and BRCA2 mutation carriers. Breast Cancer Res. Treat., 157 (2). S. 319 - 328. NEW YORK: SPRINGER. ISSN 1573-7217

Full text not available from this repository.

Abstract

Female BRCA1/BRCA2 mutation carriers are at substantially increased risk for developing breast and/or ovarian cancer, and are offered enhanced surveillance including screening from a young age and risk-reducing surgery (RRS)-mastectomy (RRM) and/or salpingo-oophorectomy (RRSO). While there are established guidelines for early detection of breast cancer in high-risk women who have not undergone RRM, there are less developed guidelines after RRM. We evaluated the schemes offered before and after RRS in internationally diverse high-risk clinics. An e-mailed survey was distributed to high-risk clinics affiliated with CIMBA. Overall, 22 centers from 16 countries responded. Pre RRS surveillance schemes overwhelmingly included breast imaging (primarily MRI) from 18 to 30 years and clinical breast exam (CBE) at 6-12 month intervals. For ovarian cancer, all but 6 centers offered semiannual/annual gynecological exam, transvaginal ultrasound, and CA 125 measurements. Post RRM, most centers offered only annual CBE while 4 centers offered annual MRI, primarily for substantial residual breast tissue. After RRSO only 4 centers offered specific gynecological surveillance. Existing guidelines for breast/ovarian cancer detection in BRCA carriers are being applied pre RRS but are not globally harmonized, and most centers offer no specific surveillance post RRS. From this comprehensive multinational study it is clear that evidence-based, long-term prospective data on the most effective scheme for BRCA carriers post RRS is needed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Madorsky-Feldman, DanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sklair-Levy, MiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perri, TamarUNSPECIFIEDorcid.org/0000-0002-4042-6554UNSPECIFIED
Laitman, YaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paluch-Shimon, ShaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lester, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karlan, Beth Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singer, Christian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Maerken, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claes, KathleenUNSPECIFIEDorcid.org/0000-0003-0841-7372UNSPECIFIED
Brunet, JoanUNSPECIFIEDorcid.org/0000-0003-1945-3512UNSPECIFIED
Izquierdo, AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teule, AlexUNSPECIFIEDorcid.org/0000-0003-0028-7200UNSPECIFIED
Lee, Jong WonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, Sung-WonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arun, BanuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakubowska, AnnaUNSPECIFIEDorcid.org/0000-0002-5650-0501UNSPECIFIED
Lubinski, JanUNSPECIFIEDorcid.org/0000-0003-2931-3003UNSPECIFIED
Tucker, KatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poplawski, Nicola K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varesco, LilianaUNSPECIFIEDorcid.org/0000-0003-4871-6668UNSPECIFIED
Bonelli, Luigina AdaUNSPECIFIEDorcid.org/0000-0002-9034-9630UNSPECIFIED
Buys, Saundra S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mitchell, GillianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tischkowitz, MarcUNSPECIFIEDorcid.org/0000-0002-7880-0628UNSPECIFIED
Gerdes, Anne-MarieUNSPECIFIEDorcid.org/0000-0002-0328-3320UNSPECIFIED
Seynaeve, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robson, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kwong, AvaUNSPECIFIEDorcid.org/0000-0002-6968-9489UNSPECIFIED
Tung, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tessa, NalvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domchek, Susan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Godwin, Andrew K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rantala, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arver, BritaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedman, EitanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-273992
DOI: 10.1007/s10549-016-3805-0
Journal or Publication Title: Breast Cancer Res. Treat.
Volume: 157
Number: 2
Page Range: S. 319 - 328
Date: 2016
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1573-7217
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REDUCING SALPINGO-OOPHORECTOMY; OVARIAN-CANCER RISK; BREAST-CANCER; HEREDITARY BREAST; COST-EFFECTIVENESS; FOLLOW-UP; WOMEN; MAMMOGRAPHY; REDUCTION; RECOMMENDATIONSMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27399

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item