Universität zu Köln

Koy, Anne, Lin, Jean-Pierre ORCID: 0000-0001-9314-2259, Sanger, Terence D., Marks, Warren A., Mink, Jonathan W. and Timmermann, Lars (2016). Advances in management of movement disorders in children. Lancet Neurol., 15 (7). S. 719 - 736. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1474-4465

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Abstract

Movement disorders in children are causally and clinically heterogeneous and present in a challenging developmental context. Treatment options are broad ranging, from pharmacotherapy to invasive neuromodulation and experimental gene and stem cell therapies. The clinical effects of these therapies are variable and often poorly sustained, and only a few of the management strategies used in paediatric populations have been tested in randomised controlled studies with age-appropriate cohorts. Identification of the most appropriate treatment is uniquely challenging in children because of the incomplete knowledge about the pathophysiology of movement disorders and their influence on normal motor development; thus, effective therapeutic options for these children remain an unmet need. It is vital to transfer the expanding knowledge of the movement disorders into the development of novel symptomatic or, ideally, disease modifying treatments, and to assess these therapeutic strategies in appropriately designed and well done trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koy, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Jean-Pierre UNSPECIFIED orcid.org/0000-0001-9314-2259 UNSPECIFIED Sanger, Terence D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marks, Warren A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mink, Jonathan W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-274102
DOI:	10.1016/S1474-4422(16)00132-0
Journal or Publication Title:	Lancet Neurol.
Volume:	15
Number:	7
Page Range:	S. 719 - 736
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1474-4465
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; GUIDELINE DEVELOPMENT SUBCOMMITTEE; EUROPEAN CLINICAL GUIDELINES; DYSTONIC CEREBRAL-PALSY; BASAL GANGLIA DISEASE; TOURETTE-SYNDROME; BOTULINUM-TOXIN; PHARMACOLOGICAL-TREATMENT; AMERICAN ACADEMY; ALTERNATING HEMIPLEGIA Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27410