Universität zu Köln

Volz, L. J., Rehme, A. K., Michely, J., Nettekoven, C., Eickhoff, S. B., Fink, G. R. and Grefkes, C. (2016). Shaping Early Reorganization of Neural Networks Promotes Motor Function after Stroke. Cereb. Cortex, 26 (6). S. 2882 - 2895. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Neural plasticity is a major factor driving cortical reorganization after stroke. We here tested whether repetitively enhancing motor cortex plasticity by means of intermittent theta-burst stimulation (iTBS) prior to physiotherapy might promote recovery of function early after stroke. Functional magnetic resonance imaging (fMRI) was used to elucidate underlying neural mechanisms. Twenty-six hospitalized, first-ever stroke patients (time since stroke: 1-16 days) with hand motor deficits were enrolled in a sham-controlled design and pseudo-randomized into 2 groups. iTBS was administered prior to physiotherapy on 5 consecutive days either over ipsilesional primary motor cortex (M1-stimulation group) or parieto-occipital vertex (control-stimulation group). Hand motor function, cortical excitability, and resting-state fMRI were assessed 1 day prior to the first stimulation and 1 day after the last stimulation. Recovery of grip strength was significantly stronger in the M1-stimulation compared to the control-stimulation group. Higher levels of motor network connectivity were associated with better motor outcome. Consistently, control-stimulated patients featured a decrease in intra- and interhemispheric connectivity of the motor network, which was absent in the M1-stimulation group. Hence, adding iTBS to prime physiotherapy in recovering stroke patients seems to interfere with motor network degradation, possibly reflecting alleviation of post-stroke diaschisis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Volz, L. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehme, A. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Michely, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nettekoven, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, S. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-274346
DOI:	10.1093/cercor/bhw034
Journal or Publication Title:	Cereb. Cortex
Volume:	26
Number:	6
Page Range:	S. 2882 - 2895
Date:	2016
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THETA-BURST STIMULATION; UPPER-LIMB RECOVERY; CORTICAL EXCITABILITY; MOTION ARTIFACT; CONNECTIVITY; CORTEX; TMS; RESPONSES; AREAS; RTMS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27434