Universität zu Köln

Prickartz, Alexander, Luesebrink, Jessica, Khalfaoui, Soumaya, Schildgen, Oliver ORCID: 0000-0003-4297-9627, Schildgen, Verena, Windisch, Wolfram and Brockmann, Michael (2016). Low Titer Pneumocystis jirovecii Infections: More than Just Colonization? J. Fungi, 2 (2). BASEL: MDPI. ISSN 2309-608X

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Abstract

Non-pneumonia Pneumocystis jirovecii colonization is thought to occur frequently in immunocompetent individuals. The aim was to analyze if P. jirovecii low-titer detections have more impact than just colonization. From our total cohort of patients for which P. jirovecii testing by qPCR was requested, we selected exclusively those that were fully immunocompetent. Patients were defined as fully immunocompetent if they did not receive immunosuppressive therapy, displayed regular antibody titers, and did not suffer from acquired, inherited or autoimmune diseases. Only those patients with complete medical records available were included. A retrospective analysis identified patients with P. jirovecii colonization and successful antibiotic therapy in response to laboratory pathogen detection. We identified 30 fully immunocompetent patients with P. jirovecii colonization suspected to suffer from infection with the pathogen, but with milder symptoms than pneumonia. All patients were successfully treated with cotrimoxazole against P. jirovecii and resolved from chronic cough and recurrent pulmonary infections. The fact that all patients displayed recovery from their clinical symptoms gives raise to the hypothesis that P. jirovecii infections may also occur in immunocompetent patients but with milder symptoms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prickartz, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Luesebrink, Jessica UNSPECIFIED UNSPECIFIED UNSPECIFIED Khalfaoui, Soumaya UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Windisch, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-274602
DOI:	10.3390/jof2020016
Journal or Publication Title:	J. Fungi
Volume:	2
Number:	2
Date:	2016
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2309-608X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REAL-TIME PCR; BRONCHOALVEOLAR LAVAGE FLUID; POLYMERASE-CHAIN-REACTION; IMMUNOSUPPRESSED PATIENTS; CARINII-PNEUMONIA; CLINICAL-SIGNIFICANCE; TOUCH-DOWN; PATIENT; ASSAY; IMMUNOCOMPETENT Multiple languages Microbiology; Mycology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27460