Schoofs, Till, Klein, Florian, Braunschweig, Malte, Kreider, Edward F., Feldmann, Anna, Nogueira, Lilian, Oliveira, Thiago ORCID: 0000-0002-2654-0879, Lorenzi, Julio C. C., Parrish, Erica H., Learn, Gerald H., West, Anthony P., Jr., Bjorkman, Pamela J., Schlesinger, Sarah J., Seaman, Michael S., Czartoski, Julie, McElrath, M. Juliana, Pfeifer, Nico ORCID: 0000-0002-4647-8566, Hahn, Beatrice H., Caskey, Marina ORCID: 0000-0003-1727-8693 and Nussenzweig, Michel C. (2016). HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1. Science, 352 (6288). S. 997 - 1002. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

Full text not available from this repository.

Abstract

3BNC117 is a broad and potent neutralizing antibody to HIV-1 that targets the CD4 binding site on the viral envelope spike. When administered passively, this antibody can prevent infection in animal models and suppress viremia in HIV-1-infected individuals. Here we report that HIV-1 immunotherapy with a single injection of 3BNC117 affects host antibody responses in viremic individuals. In comparison to untreated controls that showed little change in their neutralizing activity over a 6-month period, 3BNC117 infusion significantly improved neutralizing responses to heterologous tier 2 viruses in nearly all study participants. We conclude that 3BNC117-mediated immunotherapy enhances host humoral immunity to HIV-1.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schoofs, TillUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braunschweig, MalteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreider, Edward F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feldmann, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogueira, LilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oliveira, ThiagoUNSPECIFIEDorcid.org/0000-0002-2654-0879UNSPECIFIED
Lorenzi, Julio C. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parrish, Erica H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Learn, Gerald H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
West, Anthony P., Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjorkman, Pamela J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlesinger, Sarah J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seaman, Michael S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czartoski, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McElrath, M. JulianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeifer, NicoUNSPECIFIEDorcid.org/0000-0002-4647-8566UNSPECIFIED
Hahn, Beatrice H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caskey, MarinaUNSPECIFIEDorcid.org/0000-0003-1727-8693UNSPECIFIED
Nussenzweig, Michel C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-275598
DOI: 10.1126/science.aaf0972
Journal or Publication Title: Science
Volume: 352
Number: 6288
Page Range: S. 997 - 1002
Date: 2016
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication: WASHINGTON
ISSN: 1095-9203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BROADLY NEUTRALIZING ANTIBODIES; GENETIC SEQUENCE DIVERSITY; 2-SAMPLE TESTS; HUMANIZED MICE; CD4 BINDING; VACCINE; MACAQUES; VIREMIA; IMMUNOTHERAPY; POPULATIONSMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27559

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item